Case of complete response to neoadjuvant therapy using nivolumab in a patient with metastatic renal cell carcinoma

Daiki Ikarashi; Yoichiro Kato; Hirokatsu Katagiri; Takeshi Takahara; Noriyuki Uesugi; Ei Shiomi; Jun Sugimura; Hiroyuki Nitta; Tamotsu Sugai; Wataru Obara

doi:10.1111/iju.13590

Case of complete response to neoadjuvant therapy using nivolumab in a patient with metastatic renal cell carcinoma

Daiki Ikarashi, Yoichiro Kato, Hirokatsu Katagiri, Takeshi Takahara, Noriyuki Uesugi, Ei Shiomi, Jun Sugimura, Hiroyuki Nitta, Tamotsu Sugai, Wataru Obara

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Here, we report a case of a 68-year-old woman with cT4N0M1 (liver invasion and multiple lung metastases) metastatic renal cell carcinoma. We could carry out less invasive nephrectomy with partial hepatectomy because nivolumab administration as second-line therapy reduced the primary tumor remarkably. To the best of our knowledge, this is the first report of the use of nivolumab before carrying out surgery, and histological findings showed a pathological complete response.

Original language	English
Pages (from-to)	630-632
Number of pages	3
Journal	International Journal of Urology
Volume	25
Issue number	6
DOIs	https://doi.org/10.1111/iju.13590
Publication status	Published - 06-2018
Externally published	Yes

All Science Journal Classification (ASJC) codes

Urology

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10.1111/iju.13590

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title = "Case of complete response to neoadjuvant therapy using nivolumab in a patient with metastatic renal cell carcinoma",

abstract = "Here, we report a case of a 68-year-old woman with cT4N0M1 (liver invasion and multiple lung metastases) metastatic renal cell carcinoma. We could carry out less invasive nephrectomy with partial hepatectomy because nivolumab administration as second-line therapy reduced the primary tumor remarkably. To the best of our knowledge, this is the first report of the use of nivolumab before carrying out surgery, and histological findings showed a pathological complete response.",

author = "Daiki Ikarashi and Yoichiro Kato and Hirokatsu Katagiri and Takeshi Takahara and Noriyuki Uesugi and Ei Shiomi and Jun Sugimura and Hiroyuki Nitta and Tamotsu Sugai and Wataru Obara",

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AU - Ikarashi, Daiki

AU - Kato, Yoichiro

AU - Katagiri, Hirokatsu

AU - Takahara, Takeshi

AU - Uesugi, Noriyuki

AU - Shiomi, Ei

AU - Sugimura, Jun

AU - Nitta, Hiroyuki

AU - Sugai, Tamotsu

AU - Obara, Wataru

PY - 2018/6

Y1 - 2018/6

N2 - Here, we report a case of a 68-year-old woman with cT4N0M1 (liver invasion and multiple lung metastases) metastatic renal cell carcinoma. We could carry out less invasive nephrectomy with partial hepatectomy because nivolumab administration as second-line therapy reduced the primary tumor remarkably. To the best of our knowledge, this is the first report of the use of nivolumab before carrying out surgery, and histological findings showed a pathological complete response.

AB - Here, we report a case of a 68-year-old woman with cT4N0M1 (liver invasion and multiple lung metastases) metastatic renal cell carcinoma. We could carry out less invasive nephrectomy with partial hepatectomy because nivolumab administration as second-line therapy reduced the primary tumor remarkably. To the best of our knowledge, this is the first report of the use of nivolumab before carrying out surgery, and histological findings showed a pathological complete response.

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Case of complete response to neoadjuvant therapy using nivolumab in a patient with metastatic renal cell carcinoma

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