Case of immediate hypersensitivity to beer

Tomoko Inoue, Akiko Yagami, Naoshi Shimojo, Kazuhiro Hara, Masashi Nakamura, Kayoko Matsunaga

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We report here a case of immediate hypersensitivity to beer, in which a female patient developed angioedema of the eyelids shortly after consuming beer. In skin prick tests, the patient showed positive reactions to the base ingredients of beer, particularly malt and barley. The specific serum immunoglobulin E antibodies against barley and malt displayed weakly positive reactivity. To identify the immunoreactive antigens, malt and barley proteins were separated by 2-D polyacrylamide gel electrophoresis and immunoreacted with the patient's serum. The results of mass spectrometric analysis revealed that the main antigen was a protein with similarity to protein z-type serpin. Notably, the identified antigen had a molecular weight of 20-25 kDa, which is markedly smaller than that previously reported for protein Z4 (44 kDa). Taken together, these analyses indicate that a possible new antigen which belongs to the protein Z family elicits immediate hypersensitivity to beer.

Original languageEnglish
Pages (from-to)690-692
Number of pages3
JournalJournal of Dermatology
Issue number6
Publication statusPublished - 01-06-2016


All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Inoue, T., Yagami, A., Shimojo, N., Hara, K., Nakamura, M., & Matsunaga, K. (2016). Case of immediate hypersensitivity to beer. Journal of Dermatology, 43(6), 690-692.