Case of immediate hypersensitivity to beer

Tomoko Inoue, Akiko Yagami, Naoshi Shimojo, Kazuhiro Hara, Masashi Nakamura, Kayoko Matsunaga

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We report here a case of immediate hypersensitivity to beer, in which a female patient developed angioedema of the eyelids shortly after consuming beer. In skin prick tests, the patient showed positive reactions to the base ingredients of beer, particularly malt and barley. The specific serum immunoglobulin E antibodies against barley and malt displayed weakly positive reactivity. To identify the immunoreactive antigens, malt and barley proteins were separated by 2-D polyacrylamide gel electrophoresis and immunoreacted with the patient's serum. The results of mass spectrometric analysis revealed that the main antigen was a protein with similarity to protein z-type serpin. Notably, the identified antigen had a molecular weight of 20-25 kDa, which is markedly smaller than that previously reported for protein Z 4 (44 kDa). Taken together, these analyses indicate that a possible new antigen which belongs to the protein Z family elicits immediate hypersensitivity to beer.

Original languageEnglish
Pages (from-to)690-692
Number of pages3
JournalJournal of Dermatology
Volume43
Issue number6
DOIs
Publication statusPublished - 01-06-2016

Fingerprint

Immediate Hypersensitivity
Hordeum
Antigens
Serpins
Angioedema
Proteins
Electrophoresis, Gel, Two-Dimensional
Eyelids
Skin Tests
Serum
Immunoglobulin E
Molecular Weight
Antibodies
plasma protein Z

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Inoue, T., Yagami, A., Shimojo, N., Hara, K., Nakamura, M., & Matsunaga, K. (2016). Case of immediate hypersensitivity to beer. Journal of Dermatology, 43(6), 690-692. https://doi.org/10.1111/1346-8138.13210
Inoue, Tomoko ; Yagami, Akiko ; Shimojo, Naoshi ; Hara, Kazuhiro ; Nakamura, Masashi ; Matsunaga, Kayoko. / Case of immediate hypersensitivity to beer. In: Journal of Dermatology. 2016 ; Vol. 43, No. 6. pp. 690-692.
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Inoue, T, Yagami, A, Shimojo, N, Hara, K, Nakamura, M & Matsunaga, K 2016, 'Case of immediate hypersensitivity to beer', Journal of Dermatology, vol. 43, no. 6, pp. 690-692. https://doi.org/10.1111/1346-8138.13210

Case of immediate hypersensitivity to beer. / Inoue, Tomoko; Yagami, Akiko; Shimojo, Naoshi; Hara, Kazuhiro; Nakamura, Masashi; Matsunaga, Kayoko.

In: Journal of Dermatology, Vol. 43, No. 6, 01.06.2016, p. 690-692.

Research output: Contribution to journalArticle

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Inoue T, Yagami A, Shimojo N, Hara K, Nakamura M, Matsunaga K. Case of immediate hypersensitivity to beer. Journal of Dermatology. 2016 Jun 1;43(6):690-692. https://doi.org/10.1111/1346-8138.13210