Case of immunoglobulin G4-related skin disease: Possible immunoglobulin G4-related skin disease cases in cutaneous pseudolymphoma only by immunohistochemical analysis

Yohei Iwata, Yoshikazu Mizoguchi, Masayuki Takahashi, Beni Tanaka, Makoto Kuroda, Akiko Yagami, Kayoko Matsunaga

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Immunoglobulin G4-related disease (IgG4-RD) is a newly recognized disease characterized by elevated serum IgG4 levels, tissue infiltration rich in IgG4 + plasma cells. We report on a case which was first considered as pseudolymphoma from the histopathological analysis, but finally diagnosed as IgG4-related skin lesions. As the morphological features of cutaneous involvement of IgG4-RD are consistent with those of cutaneous pseudolymphoma, we tried immunostaining past potential cases of IgG4-RD. Thirty-two skin specimens (15 men and 17 women; mean age, 53 years) diagnosed as having pseudolymphoma were retrieved from the archives to conduct hematoxylin-eosin, IgG and IgG4 staining. Out of the 32 cases of cutaneous pseudolymphoma, germinal center formation was seen in 22 cases, and moderate-severe fibrosis was seen in seven cases. Eleven cases showed more than 10 IgG4 + plasma cell infiltration/high-power field, and among these 11 cases, seven cases (22%) showed A ratio of IgG4 + /IgG + cells of more than 40%. Thus, out of the 32 cases of cutaneous pseudolymphomas, two cases (6.3%) satisfied IgG4-RD histopathological diagnostic criteria. As clinical presentations and histopathological features of skin involvement of IgG4-RD are analogous to cutaneous B-cell pseudolymphoma, careful identification is required through systemic examination, serum IgG4 measurement and other means.

Original languageEnglish
Pages (from-to)998-1003
Number of pages6
JournalJournal of Dermatology
Volume40
Issue number12
DOIs
Publication statusPublished - 01-12-2013

Fingerprint

Pseudolymphoma
Skin Diseases
Immunoglobulins
Immunoglobulin G
Skin
Plasma Cells
Germinal Center
Hematoxylin
Eosine Yellowish-(YS)
Serum
Fibrosis
B-Lymphocytes
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Iwata, Yohei ; Mizoguchi, Yoshikazu ; Takahashi, Masayuki ; Tanaka, Beni ; Kuroda, Makoto ; Yagami, Akiko ; Matsunaga, Kayoko. / Case of immunoglobulin G4-related skin disease : Possible immunoglobulin G4-related skin disease cases in cutaneous pseudolymphoma only by immunohistochemical analysis. In: Journal of Dermatology. 2013 ; Vol. 40, No. 12. pp. 998-1003.
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Case of immunoglobulin G4-related skin disease : Possible immunoglobulin G4-related skin disease cases in cutaneous pseudolymphoma only by immunohistochemical analysis. / Iwata, Yohei; Mizoguchi, Yoshikazu; Takahashi, Masayuki; Tanaka, Beni; Kuroda, Makoto; Yagami, Akiko; Matsunaga, Kayoko.

In: Journal of Dermatology, Vol. 40, No. 12, 01.12.2013, p. 998-1003.

Research output: Contribution to journalArticle

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T2 - Possible immunoglobulin G4-related skin disease cases in cutaneous pseudolymphoma only by immunohistochemical analysis

AU - Iwata, Yohei

AU - Mizoguchi, Yoshikazu

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AU - Tanaka, Beni

AU - Kuroda, Makoto

AU - Yagami, Akiko

AU - Matsunaga, Kayoko

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