Case of limbic encephalitis with anti-neutral glycosphingolipid antibodies

Yuko Takeuchi, Miki Ueda, Jun Ochiai, Chiyuki Mabuchi, Sayuri Shima, Tatsuro Mutoh

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


We describe a case of a 44-year-old man with limbic encephalitis and refractory epileptic seizure. He was found to have developed flaccid paraplegia when he recovered from status epilepticus. Electrophysiological examinations disclosed axonal neuropathy of the lower limbs with nerve roots involvement. Brain fluid-attenuated inversion recovery-weighted magnetic resonance imaging showed bilateral medial temporal hyperintensities. Anti-neutral glycolipid antibodies were detected in the acute phase serum, but disappeared after immunomodulatory therapy. A previous study has shown that anti-neutral glycolipid antibodies are present in encephalomyeloradiculoneuropathy cases. The present patient initially showed limbic encephalitis phenotype followed by involvement of nerve roots and peripheral nerves, just like in previous encephalomyeloradiculoneuropathy cases. The present case strongly suggests that ncephalomyeloradiculoneuropathy might include a phenotype of limbic encephalitis, although we do not have definite grounds for this assumption, which remains to be elucidated. Nevertheless, examination of anti-neutral glycolipids antibodies is highly recommended for future similar cases.

Original languageEnglish
Pages (from-to)70-72
Number of pages3
JournalNeurology and Clinical Neuroscience
Issue number2
Publication statusPublished - 01-03-2016

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology


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