Case of polyhydramnios complicated by Opitz G/BBB syndrome

Hiroko Tajima, Hiroaki Itoh, Ayako Mochizuki, Yuki Nakamura, Yukiko Kobayashi, Kyuya Hirai, Kazunao Suzuki, Kazuhiro Sugihara, Akira Ohishi, Takehiko Ohzeki, Naohiro Kanayama

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Opitz G/BBB syndrome is a congenital disorder characterized by midline defects, such as hypertelorism, cleft lip and/or palate, hypospadias, and by dysphagia often caused by laryngo-tracheo-esophageal abnormalities. We experienced a case of polyhydramnios in a male dichorionic diamniotic (DD) twin, who was diagnosed with Opitz G/BBB syndrome after birth. It is suggested that severe dysphagia was causatively associated with the development of polyhydramnios. In cases of Opitz G/BBB syndrome, boys are usually more heavily affected than girls, who generally manifest only hypertelorism. In the differential diagnosis of polyhydramnios of unidentified cause in male fetuses, it may be helpful to consider maternal facial characteristics, especially hypertelorism.

Original languageEnglish
Pages (from-to)876-881
Number of pages6
JournalJournal of Obstetrics and Gynaecology Research
Issue number4
Publication statusPublished - 08-2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology


Dive into the research topics of 'Case of polyhydramnios complicated by Opitz G/BBB syndrome'. Together they form a unique fingerprint.

Cite this