Case of relapsed relapsed AIDS-related plasmablastic lymphoma treated with autologous srem cell transplantation and highly active antiretroviral therapy

Hiroki Goto; Shotaro Hagiwara; Risen Hirai; Takahiko Miyama; Haruhito Honda; Amane Tagashira; Toshihiko Iizuka; Makoto Mochizuki; Katsuji Teruya; Yoshimi Kikuchi; Shinichi Oka; Akiyoshi Miwa

doi:10.4081/rt.2011.e11

Case of relapsed relapsed AIDS-related plasmablastic lymphoma treated with autologous srem cell transplantation and highly active antiretroviral therapy

Hiroki Goto, Shotaro Hagiwara, Risen Hirai, Takahiko Miyama, Haruhito Honda, Amane Tagashira, Toshihiko Iizuka, Makoto Mochizuki, Katsuji Teruya, Yoshimi Kikuchi, Shinichi Oka, Akiyoshi Miwa

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Plasmablastic lymphoma is a rare and aggressive malignancy strongly associated with HIV infection. The refractory/relapsed disease rate is high, and the survival rate is characteristically poor. There are no satisfactory salvage regimens for relapsed cases. We successfully performed autologous stem cell transplantation using a regimen consisting of MCNU (ranimustine), etoposide, cytarabine, and melphalan in a Japanese patient with relapsed AIDS-related plasmablastic lymphoma of the oral cavity. Highly active antiretroviral therapy continued during the therapy. Therapy-related toxicity was tolerable, and a total of 40 Gy of irradiation was administered after autologous stem cell transplantation. The patient has remained in complete remission for 16 months since transplantation.

Original language	English
Pages (from-to)	33-35
Number of pages	3
Journal	Rare Tumors
Volume	3
Issue number	1
DOIs	https://doi.org/10.4081/rt.2011.e11
Publication status	Published - 2011
Externally published	Yes

All Science Journal Classification (ASJC) codes

Histology
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4081/rt.2011.e11

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title = "Case of relapsed relapsed AIDS-related plasmablastic lymphoma treated with autologous srem cell transplantation and highly active antiretroviral therapy",

abstract = "Plasmablastic lymphoma is a rare and aggressive malignancy strongly associated with HIV infection. The refractory/relapsed disease rate is high, and the survival rate is characteristically poor. There are no satisfactory salvage regimens for relapsed cases. We successfully performed autologous stem cell transplantation using a regimen consisting of MCNU (ranimustine), etoposide, cytarabine, and melphalan in a Japanese patient with relapsed AIDS-related plasmablastic lymphoma of the oral cavity. Highly active antiretroviral therapy continued during the therapy. Therapy-related toxicity was tolerable, and a total of 40 Gy of irradiation was administered after autologous stem cell transplantation. The patient has remained in complete remission for 16 months since transplantation.",

author = "Hiroki Goto and Shotaro Hagiwara and Risen Hirai and Takahiko Miyama and Haruhito Honda and Amane Tagashira and Toshihiko Iizuka and Makoto Mochizuki and Katsuji Teruya and Yoshimi Kikuchi and Shinichi Oka and Akiyoshi Miwa",

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doi = "10.4081/rt.2011.e11",

language = "English",

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T1 - Case of relapsed relapsed AIDS-related plasmablastic lymphoma treated with autologous srem cell transplantation and highly active antiretroviral therapy

AU - Goto, Hiroki

AU - Hagiwara, Shotaro

AU - Hirai, Risen

AU - Miyama, Takahiko

AU - Honda, Haruhito

AU - Tagashira, Amane

AU - Iizuka, Toshihiko

AU - Mochizuki, Makoto

AU - Teruya, Katsuji

AU - Kikuchi, Yoshimi

AU - Oka, Shinichi

AU - Miwa, Akiyoshi

PY - 2011

Y1 - 2011

N2 - Plasmablastic lymphoma is a rare and aggressive malignancy strongly associated with HIV infection. The refractory/relapsed disease rate is high, and the survival rate is characteristically poor. There are no satisfactory salvage regimens for relapsed cases. We successfully performed autologous stem cell transplantation using a regimen consisting of MCNU (ranimustine), etoposide, cytarabine, and melphalan in a Japanese patient with relapsed AIDS-related plasmablastic lymphoma of the oral cavity. Highly active antiretroviral therapy continued during the therapy. Therapy-related toxicity was tolerable, and a total of 40 Gy of irradiation was administered after autologous stem cell transplantation. The patient has remained in complete remission for 16 months since transplantation.

AB - Plasmablastic lymphoma is a rare and aggressive malignancy strongly associated with HIV infection. The refractory/relapsed disease rate is high, and the survival rate is characteristically poor. There are no satisfactory salvage regimens for relapsed cases. We successfully performed autologous stem cell transplantation using a regimen consisting of MCNU (ranimustine), etoposide, cytarabine, and melphalan in a Japanese patient with relapsed AIDS-related plasmablastic lymphoma of the oral cavity. Highly active antiretroviral therapy continued during the therapy. Therapy-related toxicity was tolerable, and a total of 40 Gy of irradiation was administered after autologous stem cell transplantation. The patient has remained in complete remission for 16 months since transplantation.

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DO - 10.4081/rt.2011.e11

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JO - Rare Tumors

JF - Rare Tumors

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Case of relapsed relapsed AIDS-related plasmablastic lymphoma treated with autologous srem cell transplantation and highly active antiretroviral therapy

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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