Case report: A case of severe retropharyngeal edema after COVID-19 successfully treated with intravenous immunoglobulin

Takanori Suzuki, Toya Kono, Hisada Satoshi, Hidetoshi Uchida, Seiichiro Ota, Ichiro Tateya, Tetsushi Yoshikawa

Research output: Contribution to journalArticlepeer-review

Abstract

Multisystem inflammatory syndrome in children (MIS-C) has been widely reported, mainly in Western countries. The clinical features of MIS-C and Kawasaki disease are similar. The latter is common in Asian countries, including Japan. Meanwhile, the incidence of MIS-C seems to be low in Japan. Retropharyngeal edema is relatively common in older patients with Kawasaki disease and has been reported in a few patients with MIS-C. We describe a case of severe retropharyngeal edema after coronavirus disease 2019 (COVID-19) that improved quickly with high-dose of intravenous immunoglobulin treatment. Onset of retropharyngeal edema was 3 weeks after COVID-19. The patient received appropriate intravenous antibiotics for 5 days, but his symptoms worsened. Therefore, we suspected that his retropharyngeal edema was caused by suspected MIS-C even though he did not have the typical clinical symptoms of suspected MIS-C such as gastrointestinal symptoms and shock. Retropharyngeal edema was refractory to antibiotic therapy but lessened quickly with high-dose immunoglobulin therapy, without other typical clinical manifestations of MIS-C, suggesting that early immunoglobulin therapy might prevent the progression of MIS-C.

Original languageEnglish
Article number1198505
JournalFrontiers in Pediatrics
Volume11
DOIs
Publication statusPublished - 2023

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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