Case Report: Management of Cholestasis Associated With Congenital Syphilis

Kotaro Ogawa, Koya Kawase, Tokio Sugiura, Toshihiro Yasui, Seiya Yamagata, Tamao Watanabe, Yoshikazu Kawabe

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Cholestasis is a rare but life-threatening complication of congenital syphilis. However, standard management methods for this disease have not been established. Here, we report a case of congenital syphilis presenting with progressively worsening cholestasis, and we review the clinical features and management practices. In these cases, differentiation from other diseases presenting with cholestasis during the neonatal period, such as biliary atresia, is critical. In this regard, operative cholangiogram and histopathological analysis of the liver are required. Moreover, comprehensive genetic analysis can be useful. Although there is no specific treatment for cholestasis associated with congenital syphilis, appropriate nutritional management and supplementation with fat-soluble vitamins, especially vitamin K, should be provided. The severity of liver fibrosis may affect the prognosis of cholestasis associated with congenital syphilis. Therefore, attention should be paid to liver fibrosis in these patients.

Original languageEnglish
Article number607506
JournalFrontiers in Pediatrics
Publication statusPublished - 11-12-2020

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Case Report: Management of Cholestasis Associated With Congenital Syphilis'. Together they form a unique fingerprint.

Cite this