Case report of severe myocarditis in an immunocompromised child with Respiratory Syncytial Virus infection

Hiroki Miura, Fumihiko Hattori, Hidetoshi Uchida, Tadayoshi Hata, Kazuko Kudo, Masatoki Sato, Tetsushi Yoshikawa

Research output: Contribution to journalArticle

Abstract

Background: Respiratory syncytial virus (RSV) infection is common and may be severe among patients with preexisting cardiac anomalies, but direct involvement of myocardial damage is not common in those patients. Additionally, myocardial involvement has been rarely described among immune compromised children. Case presentation: A 4-year-old girl with acute lymphoblastic leukemia who received maintenance chemotherapy in an outpatient clinic developed systemic inflammatory response syndrome. RSV infection was confirmed by a positive rapid antigen test and serological assay. Subsequently, she was diagnosed with severe myocarditis caused by RSV infection, which was diagnosed by abnormal findings of cardiac echography and ECG and elevated biomarkers for myocardial damage. Then, she was treated in the intensive care unit for 13days. High amounts of RSV type B RNA was detected in tracheal aspirates and serum sample. Conclusion: This case report emphasizes that RSV infection may be associated with myocarditis in immunocompromised children receiving maintenance chemotherapy.

Original languageEnglish
Article number51
JournalBMC Pediatrics
Volume18
Issue number1
DOIs
Publication statusPublished - 12-02-2018

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Respiratory Syncytial Virus Infections
Myocarditis
Maintenance Chemotherapy
Systemic Inflammatory Response Syndrome
Respiratory Syncytial Viruses
Serologic Tests
Ambulatory Care Facilities
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Intensive Care Units
Ultrasonography
Electrocardiography
Biomarkers
RNA
Antigens
Serum

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

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title = "Case report of severe myocarditis in an immunocompromised child with Respiratory Syncytial Virus infection",
abstract = "Background: Respiratory syncytial virus (RSV) infection is common and may be severe among patients with preexisting cardiac anomalies, but direct involvement of myocardial damage is not common in those patients. Additionally, myocardial involvement has been rarely described among immune compromised children. Case presentation: A 4-year-old girl with acute lymphoblastic leukemia who received maintenance chemotherapy in an outpatient clinic developed systemic inflammatory response syndrome. RSV infection was confirmed by a positive rapid antigen test and serological assay. Subsequently, she was diagnosed with severe myocarditis caused by RSV infection, which was diagnosed by abnormal findings of cardiac echography and ECG and elevated biomarkers for myocardial damage. Then, she was treated in the intensive care unit for 13days. High amounts of RSV type B RNA was detected in tracheal aspirates and serum sample. Conclusion: This case report emphasizes that RSV infection may be associated with myocarditis in immunocompromised children receiving maintenance chemotherapy.",
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Case report of severe myocarditis in an immunocompromised child with Respiratory Syncytial Virus infection. / Miura, Hiroki; Hattori, Fumihiko; Uchida, Hidetoshi; Hata, Tadayoshi; Kudo, Kazuko; Sato, Masatoki; Yoshikawa, Tetsushi.

In: BMC Pediatrics, Vol. 18, No. 1, 51, 12.02.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Case report of severe myocarditis in an immunocompromised child with Respiratory Syncytial Virus infection

AU - Miura, Hiroki

AU - Hattori, Fumihiko

AU - Uchida, Hidetoshi

AU - Hata, Tadayoshi

AU - Kudo, Kazuko

AU - Sato, Masatoki

AU - Yoshikawa, Tetsushi

PY - 2018/2/12

Y1 - 2018/2/12

N2 - Background: Respiratory syncytial virus (RSV) infection is common and may be severe among patients with preexisting cardiac anomalies, but direct involvement of myocardial damage is not common in those patients. Additionally, myocardial involvement has been rarely described among immune compromised children. Case presentation: A 4-year-old girl with acute lymphoblastic leukemia who received maintenance chemotherapy in an outpatient clinic developed systemic inflammatory response syndrome. RSV infection was confirmed by a positive rapid antigen test and serological assay. Subsequently, she was diagnosed with severe myocarditis caused by RSV infection, which was diagnosed by abnormal findings of cardiac echography and ECG and elevated biomarkers for myocardial damage. Then, she was treated in the intensive care unit for 13days. High amounts of RSV type B RNA was detected in tracheal aspirates and serum sample. Conclusion: This case report emphasizes that RSV infection may be associated with myocarditis in immunocompromised children receiving maintenance chemotherapy.

AB - Background: Respiratory syncytial virus (RSV) infection is common and may be severe among patients with preexisting cardiac anomalies, but direct involvement of myocardial damage is not common in those patients. Additionally, myocardial involvement has been rarely described among immune compromised children. Case presentation: A 4-year-old girl with acute lymphoblastic leukemia who received maintenance chemotherapy in an outpatient clinic developed systemic inflammatory response syndrome. RSV infection was confirmed by a positive rapid antigen test and serological assay. Subsequently, she was diagnosed with severe myocarditis caused by RSV infection, which was diagnosed by abnormal findings of cardiac echography and ECG and elevated biomarkers for myocardial damage. Then, she was treated in the intensive care unit for 13days. High amounts of RSV type B RNA was detected in tracheal aspirates and serum sample. Conclusion: This case report emphasizes that RSV infection may be associated with myocarditis in immunocompromised children receiving maintenance chemotherapy.

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