TY - JOUR
T1 - Caveolae
T2 - From a morphological point of view
AU - Fujimoto, Toyoshi
AU - Hagiwara, Haruo
AU - Aoki, Takeo
AU - Kogo, Hiroshi
AU - Nomura, Ryuji
PY - 1998
Y1 - 1998
N2 - Caveolae in the plasma membrane have been a focus of intensive research during the past several years. There has been confusion concerning caveolae and caveola-like membrane domains, but it is now generally thought that the latter is a region distinct from caveolae. However, due to similar buoyancy of caveolae and caveola-like membranes, whether caveolae in situ are enriched with a given molecule is often difficult to be concluded by biochemical techniques alone. Furthermore, relatively shallow caveolae may be detected by some techniques, but not by others. Thus whether a molecule is enriched in caveolae should be confirmed by methods based on different principles. Among many putative caveolar molecules, those related to Ca2+ influx and extrusion were shown to be concentrated in caveolae by both immunocytochemical and biochemical techniques. In conjunction with other characteristics, the result implies that caveolae may function as a mobile compartment for Ca2+ signalling.
AB - Caveolae in the plasma membrane have been a focus of intensive research during the past several years. There has been confusion concerning caveolae and caveola-like membrane domains, but it is now generally thought that the latter is a region distinct from caveolae. However, due to similar buoyancy of caveolae and caveola-like membranes, whether caveolae in situ are enriched with a given molecule is often difficult to be concluded by biochemical techniques alone. Furthermore, relatively shallow caveolae may be detected by some techniques, but not by others. Thus whether a molecule is enriched in caveolae should be confirmed by methods based on different principles. Among many putative caveolar molecules, those related to Ca2+ influx and extrusion were shown to be concentrated in caveolae by both immunocytochemical and biochemical techniques. In conjunction with other characteristics, the result implies that caveolae may function as a mobile compartment for Ca2+ signalling.
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U2 - 10.1093/oxfordjournals.jmicro.a023616
DO - 10.1093/oxfordjournals.jmicro.a023616
M3 - Article
C2 - 9881454
AN - SCOPUS:0031742282
SN - 0022-0744
VL - 47
SP - 451
EP - 460
JO - Journal of Electron Microscopy
JF - Journal of Electron Microscopy
IS - 5
ER -