Abstract
Extrahepatic bile duct carcinoma (EBDC) is a malignancy well known for its poor prognosis. Some clinicopathological prognostic markers have been proposed, but genetic factors have not been well investigated. We have examined expression patterns of caveolin-1, which has been shown to function as a tumour suppressor in vitro, in EBDC using immunohistochemistry. Normal tissues adjacent to the tumour cells did not show immunoreactivity for caveolin-1. A total of 22 of the 60-carcinoma tissue samples (36.7%) studied were positive for caveolin-1. Caveolin-1 immunostaining negatively correlated with the patient's age and pathological T factor (pT) in a statistically significant manner. Multivariate analysis using Cox's proportional hazards model identified caveolin-1 expression as an independent positive prognostic factor. Thus, our study suggests that caveolin-1 expression may be a useful prognostic marker for EBDC.
| Original language | English |
|---|---|
| Pages (from-to) | 1234-1238 |
| Number of pages | 5 |
| Journal | British Journal of Cancer |
| Volume | 88 |
| Issue number | 8 |
| Publication status | Published - 22-04-2003 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
