CD109, a new marker for myoepithelial cells of mammary, salivary, and lacrimal glands and prostate basal cells

Masaki Hasegawa, Sumitaka Hagiwara, Tomoko Sato, Mayumi Jijiwa, Yoshiki Murakumo, Masahiro Maeda, Suzuko Moritani, Shu Ichihara, Masahide Takahashi

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

The CD109 gene encodes a glycosylphosphatidylinositol (GPI)-anchored cell surface protein. Herein it is shown that CD109 is highly expressed in myoepithelial cells of mammary, salivary, and lacrimal glands; and in prostate basal cells. The anti-CD109 antibody generated by the authors was available for formalin-fixed paraffin section, and it strongly stained myoepithelial cells and basal cells but not ductal, acinar, and secretory cells in these glands. CD109 expression was negative in examined breast ductal carcinomas and prostate adenocarcinomas. These findings indicate that CD109 is a useful marker for the diagnosis of invasive breast and prostate carcinomas.

Original languageEnglish
Pages (from-to)245-250
Number of pages6
JournalPathology International
Volume57
Issue number5
DOIs
Publication statusPublished - 05-2007

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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