CD109 deficiency induces osteopenia with an osteoporosis-like phenotype in vivo

Shinji Mii, Akiyoshi Hoshino, Atsushi Enomoto, Yoshiki Murakumo, Masako Ito, Akira Yamaguchi, Masahide Takahashi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Osteoporosis is a global public health problem that is increasing along with an aging population. A major determinant of osteoporosis is high bone turnover, which results from osteoclast activation. CD109 is a glycosylphosphatidylinositol-anchored glycoprotein, a deficiency that leads to a psoriasis-like skin inflammation in mice. Although the expression of CD109 has been reported in mouse pre-osteoclast cells, its function in osteoclasts in vivo remains largely unknown. To investigate the physiological role of CD109 in bone metabolism, we analyzed bones from wild-type and CD109-deficient adult mice. Micro-computed tomography analysis of the femur (thigh bone) showed that bone volume was lower in CD109-deficient mice than in wild-type mice. Bone histomorphometric analysis showed not only a reduction in bone volume but also an increase in bone turnover in CD109-deficient mice as compared with wild-type mice. Additionally, we measured serum levels of several markers of bone turnover and found a significant increase in the N-terminal telopeptide of type I collagen, a bone resorption marker, as well as alkaline phosphatase, a bone formation marker, in CD109-deficient mice. These results indicate that CD109 deficiency induces a high-turnover, osteoporosis-like phenotype, which suggests that CD109 plays a role in bone metabolism in vivo.

Original languageEnglish
Pages (from-to)590-598
Number of pages9
JournalGenes to Cells
Volume23
Issue number7
DOIs
Publication statusPublished - 07-2018

All Science Journal Classification (ASJC) codes

  • Genetics
  • Cell Biology

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    Mii, S., Hoshino, A., Enomoto, A., Murakumo, Y., Ito, M., Yamaguchi, A., & Takahashi, M. (2018). CD109 deficiency induces osteopenia with an osteoporosis-like phenotype in vivo. Genes to Cells, 23(7), 590-598. https://doi.org/10.1111/gtc.12593