CD147/basigin reflects renal dysfunction in patients with acute kidney injury

Hiroshi Nagaya, Tomoki Kosugi, Mayuko Maeda-Hori, Kayaho Maeda, Yuka Sato, Hiroshi Kojima, Hiroki Hayashi, Noritoshi Kato, Takuji Ishimoto, Waichi Sato, Yukio Yuzawa, Seiichi Matsuo, Kenji Kadomatsu, Shoichi Maruyama

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Acute tubular necrosis (ATN) describes a form of intrinsic acute kidney injury (AKI) that results from persistent hypoperfusion and subsequent activation of the immune system. A glycosylated transmembrane protein, CD147/basigin, is involved in the pathogenesis of renal ischemia and fibrosis. The present study investigated whether CD147 can reflect pathological features and renal dysfunction in patients with AKI.

Methods: Plasma and spot urine samples were collected from 24 patients (12 controls and 12 with ATN) who underwent renal biopsy between 2008 and 2012. In another study, patients undergoing open surgery to treat abdominal aortic aneurysms (AAAs) were enrolled in 2004. We collected urine and plasma samples from seven patients with AKI and 33 patients without AKI, respectively. In these experiments, plasma and urinary CD147, and urinary l-fatty acid-binding protein (l-FABP) levels were measured, and the former expression in kidneys was examined by immunostaining.

Results: In biopsy tissues of ATN with severe histological features, CD147 induction was strikingly present in inflammatory cells such as macrophages and lymphocytes in the injured interstitium, but not in damaged tubules representing atrophy. Both plasma and urinary CD147 levels were strikingly increased in ATN patients; both values showed greater correlations with renal dysfunction compared to urinary l-FABP. In patients who had undergone open AAA surgery, urinary and plasma CD147 values in AKI patients were significantly higher than in non-AKI patients at post-operative day 1, similar to the profile of urinary l-FABP.

Conclusion: CD147 was prominent in its ability to detect AKI and may allow the start of preemptive medication.

Original languageEnglish
Pages (from-to)746-754
Number of pages9
JournalClinical and Experimental Nephrology
Volume18
Issue number5
DOIs
Publication statusPublished - 11-10-2014

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CD147 Antigens
Acute Kidney Injury
Kidney
Fatty Acid-Binding Proteins
Necrosis
Abdominal Aortic Aneurysm
Urine
Biopsy
Atrophy
Immune System
Fibrosis
Ischemia
Macrophages

All Science Journal Classification (ASJC) codes

  • Physiology
  • Nephrology
  • Physiology (medical)

Cite this

Nagaya, H., Kosugi, T., Maeda-Hori, M., Maeda, K., Sato, Y., Kojima, H., ... Maruyama, S. (2014). CD147/basigin reflects renal dysfunction in patients with acute kidney injury. Clinical and Experimental Nephrology, 18(5), 746-754. https://doi.org/10.1007/s10157-013-0916-3
Nagaya, Hiroshi ; Kosugi, Tomoki ; Maeda-Hori, Mayuko ; Maeda, Kayaho ; Sato, Yuka ; Kojima, Hiroshi ; Hayashi, Hiroki ; Kato, Noritoshi ; Ishimoto, Takuji ; Sato, Waichi ; Yuzawa, Yukio ; Matsuo, Seiichi ; Kadomatsu, Kenji ; Maruyama, Shoichi. / CD147/basigin reflects renal dysfunction in patients with acute kidney injury. In: Clinical and Experimental Nephrology. 2014 ; Vol. 18, No. 5. pp. 746-754.
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Nagaya, H, Kosugi, T, Maeda-Hori, M, Maeda, K, Sato, Y, Kojima, H, Hayashi, H, Kato, N, Ishimoto, T, Sato, W, Yuzawa, Y, Matsuo, S, Kadomatsu, K & Maruyama, S 2014, 'CD147/basigin reflects renal dysfunction in patients with acute kidney injury', Clinical and Experimental Nephrology, vol. 18, no. 5, pp. 746-754. https://doi.org/10.1007/s10157-013-0916-3

CD147/basigin reflects renal dysfunction in patients with acute kidney injury. / Nagaya, Hiroshi; Kosugi, Tomoki; Maeda-Hori, Mayuko; Maeda, Kayaho; Sato, Yuka; Kojima, Hiroshi; Hayashi, Hiroki; Kato, Noritoshi; Ishimoto, Takuji; Sato, Waichi; Yuzawa, Yukio; Matsuo, Seiichi; Kadomatsu, Kenji; Maruyama, Shoichi.

In: Clinical and Experimental Nephrology, Vol. 18, No. 5, 11.10.2014, p. 746-754.

Research output: Contribution to journalArticle

TY - JOUR

T1 - CD147/basigin reflects renal dysfunction in patients with acute kidney injury

AU - Nagaya, Hiroshi

AU - Kosugi, Tomoki

AU - Maeda-Hori, Mayuko

AU - Maeda, Kayaho

AU - Sato, Yuka

AU - Kojima, Hiroshi

AU - Hayashi, Hiroki

AU - Kato, Noritoshi

AU - Ishimoto, Takuji

AU - Sato, Waichi

AU - Yuzawa, Yukio

AU - Matsuo, Seiichi

AU - Kadomatsu, Kenji

AU - Maruyama, Shoichi

PY - 2014/10/11

Y1 - 2014/10/11

N2 - Background: Acute tubular necrosis (ATN) describes a form of intrinsic acute kidney injury (AKI) that results from persistent hypoperfusion and subsequent activation of the immune system. A glycosylated transmembrane protein, CD147/basigin, is involved in the pathogenesis of renal ischemia and fibrosis. The present study investigated whether CD147 can reflect pathological features and renal dysfunction in patients with AKI.Methods: Plasma and spot urine samples were collected from 24 patients (12 controls and 12 with ATN) who underwent renal biopsy between 2008 and 2012. In another study, patients undergoing open surgery to treat abdominal aortic aneurysms (AAAs) were enrolled in 2004. We collected urine and plasma samples from seven patients with AKI and 33 patients without AKI, respectively. In these experiments, plasma and urinary CD147, and urinary l-fatty acid-binding protein (l-FABP) levels were measured, and the former expression in kidneys was examined by immunostaining.Results: In biopsy tissues of ATN with severe histological features, CD147 induction was strikingly present in inflammatory cells such as macrophages and lymphocytes in the injured interstitium, but not in damaged tubules representing atrophy. Both plasma and urinary CD147 levels were strikingly increased in ATN patients; both values showed greater correlations with renal dysfunction compared to urinary l-FABP. In patients who had undergone open AAA surgery, urinary and plasma CD147 values in AKI patients were significantly higher than in non-AKI patients at post-operative day 1, similar to the profile of urinary l-FABP.Conclusion: CD147 was prominent in its ability to detect AKI and may allow the start of preemptive medication.

AB - Background: Acute tubular necrosis (ATN) describes a form of intrinsic acute kidney injury (AKI) that results from persistent hypoperfusion and subsequent activation of the immune system. A glycosylated transmembrane protein, CD147/basigin, is involved in the pathogenesis of renal ischemia and fibrosis. The present study investigated whether CD147 can reflect pathological features and renal dysfunction in patients with AKI.Methods: Plasma and spot urine samples were collected from 24 patients (12 controls and 12 with ATN) who underwent renal biopsy between 2008 and 2012. In another study, patients undergoing open surgery to treat abdominal aortic aneurysms (AAAs) were enrolled in 2004. We collected urine and plasma samples from seven patients with AKI and 33 patients without AKI, respectively. In these experiments, plasma and urinary CD147, and urinary l-fatty acid-binding protein (l-FABP) levels were measured, and the former expression in kidneys was examined by immunostaining.Results: In biopsy tissues of ATN with severe histological features, CD147 induction was strikingly present in inflammatory cells such as macrophages and lymphocytes in the injured interstitium, but not in damaged tubules representing atrophy. Both plasma and urinary CD147 levels were strikingly increased in ATN patients; both values showed greater correlations with renal dysfunction compared to urinary l-FABP. In patients who had undergone open AAA surgery, urinary and plasma CD147 values in AKI patients were significantly higher than in non-AKI patients at post-operative day 1, similar to the profile of urinary l-FABP.Conclusion: CD147 was prominent in its ability to detect AKI and may allow the start of preemptive medication.

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U2 - 10.1007/s10157-013-0916-3

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