CD22 serves as a receptor for soluble IgM

Takahiro Adachi, Satoru Harumiya, Hiromu Takematsu, Yasunori Kozutsumi, Matthias Wabl, Manabu Fujimoto, Thomas F. Tedder

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)


CD22 (Siglec-2) is a B-cell membrane-bound lectin that recognizes glycan ligands containing α2,6-linked sialic acid (α2,6Sia) and negatively regulates signaling through the B-cell Ag receptor (BCR). Although CD22 has been investigated extensively, its precise function remains unclear due to acting multiple phases. Here, we demonstrate that CD22 is efficiently activated in trans by complexes of Ag and soluble IgM (sIgM) due to the presence of glycan ligands on sIgM. This result strongly suggests sIgM as a natural trans ligand for CD22. Also, CD22 appears to serve as a receptor for sIgM, which induces a negative feedback loop for B-cell activation similar to the Fc receptor for IgG (FcγRIIB).

Original languageEnglish
Pages (from-to)241-247
Number of pages7
JournalEuropean Journal of Immunology
Issue number1
Publication statusPublished - 01-2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology


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