CD22 serves as a receptor for soluble IgM

Takahiro Adachi; Satoru Harumiya; Hiromu Takematsu; Yasunori Kozutsumi; Matthias Wabl; Manabu Fujimoto; Thomas F. Tedder

doi:10.1002/eji.201141899

CD22 serves as a receptor for soluble IgM

Takahiro Adachi, Satoru Harumiya, Hiromu Takematsu, Yasunori Kozutsumi, Matthias Wabl, Manabu Fujimoto, Thomas F. Tedder

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

CD22 (Siglec-2) is a B-cell membrane-bound lectin that recognizes glycan ligands containing α2,6-linked sialic acid (α2,6Sia) and negatively regulates signaling through the B-cell Ag receptor (BCR). Although CD22 has been investigated extensively, its precise function remains unclear due to acting multiple phases. Here, we demonstrate that CD22 is efficiently activated in trans by complexes of Ag and soluble IgM (sIgM) due to the presence of glycan ligands on sIgM. This result strongly suggests sIgM as a natural trans ligand for CD22. Also, CD22 appears to serve as a receptor for sIgM, which induces a negative feedback loop for B-cell activation similar to the Fc receptor for IgG (FcγRIIB).

Original language	English
Pages (from-to)	241-247
Number of pages	7
Journal	European Journal of Immunology
Volume	42
Issue number	1
DOIs	https://doi.org/10.1002/eji.201141899
Publication status	Published - 01-2012
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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10.1002/eji.201141899

Cite this

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title = "CD22 serves as a receptor for soluble IgM",

abstract = "CD22 (Siglec-2) is a B-cell membrane-bound lectin that recognizes glycan ligands containing α2,6-linked sialic acid (α2,6Sia) and negatively regulates signaling through the B-cell Ag receptor (BCR). Although CD22 has been investigated extensively, its precise function remains unclear due to acting multiple phases. Here, we demonstrate that CD22 is efficiently activated in trans by complexes of Ag and soluble IgM (sIgM) due to the presence of glycan ligands on sIgM. This result strongly suggests sIgM as a natural trans ligand for CD22. Also, CD22 appears to serve as a receptor for sIgM, which induces a negative feedback loop for B-cell activation similar to the Fc receptor for IgG (FcγRIIB).",

keywords = "B cells, CD22, Fc receptor, IgM, Siglec-2",

author = "Takahiro Adachi and Satoru Harumiya and Hiromu Takematsu and Yasunori Kozutsumi and Matthias Wabl and Manabu Fujimoto and Tedder, {Thomas F.}",

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T1 - CD22 serves as a receptor for soluble IgM

AU - Adachi, Takahiro

AU - Harumiya, Satoru

AU - Takematsu, Hiromu

AU - Kozutsumi, Yasunori

AU - Wabl, Matthias

AU - Fujimoto, Manabu

AU - Tedder, Thomas F.

PY - 2012/1

Y1 - 2012/1

N2 - CD22 (Siglec-2) is a B-cell membrane-bound lectin that recognizes glycan ligands containing α2,6-linked sialic acid (α2,6Sia) and negatively regulates signaling through the B-cell Ag receptor (BCR). Although CD22 has been investigated extensively, its precise function remains unclear due to acting multiple phases. Here, we demonstrate that CD22 is efficiently activated in trans by complexes of Ag and soluble IgM (sIgM) due to the presence of glycan ligands on sIgM. This result strongly suggests sIgM as a natural trans ligand for CD22. Also, CD22 appears to serve as a receptor for sIgM, which induces a negative feedback loop for B-cell activation similar to the Fc receptor for IgG (FcγRIIB).

AB - CD22 (Siglec-2) is a B-cell membrane-bound lectin that recognizes glycan ligands containing α2,6-linked sialic acid (α2,6Sia) and negatively regulates signaling through the B-cell Ag receptor (BCR). Although CD22 has been investigated extensively, its precise function remains unclear due to acting multiple phases. Here, we demonstrate that CD22 is efficiently activated in trans by complexes of Ag and soluble IgM (sIgM) due to the presence of glycan ligands on sIgM. This result strongly suggests sIgM as a natural trans ligand for CD22. Also, CD22 appears to serve as a receptor for sIgM, which induces a negative feedback loop for B-cell activation similar to the Fc receptor for IgG (FcγRIIB).

KW - B cells

KW - CD22

KW - Fc receptor

KW - IgM

KW - Siglec-2

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JO - European Journal of Immunology

JF - European Journal of Immunology

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CD22 serves as a receptor for soluble IgM

Abstract

All Science Journal Classification (ASJC) codes

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