CD36 gene polymorphism (rs1761667) is associated with dietary monounsaturated fatty acid intake and hypertension in a Japanese population

Ryosuke Fujii, Asahi Hishida, Koji Suzuki, Nahomi Imaeda, Chiho Goto, Nobuyuki Hamajima, Kenji Wakai, Takaaki Kondo

Research output: Contribution to journalArticle

Abstract

CD36 is a membrane receptor expressed on a wide variety of human cells. CD36 polymorphisms are reportedly associated with oral fat perception, dietary intake, and metabolic disorders. The present study examined associations of two CD36 polymorphisms (rs1761667 and rs1527483) and dietary fat intake, and metabolic phenotypes in a Japanese population. This cross-sectional study was conducted based on clinical information collected from health check-ups in Japan (n = 495). Dietary nutrient intake was estimated from a validated short food frequency questionnaire and adjusted for total energy intake using the residual method. Mean blood pressure was calculated from systolic blood pressure (SBP) and diastolic blood pressure (DBP). Hypertension was defined as SBP ≥ 130 mmHg and/or DBP ≥ 85 mmHg, or use of antihypertensive drugs. Genotyping was performed using the polymerase chain reaction with confronting two-pair primers method. Mean age (standard deviation) was 63.4 (9.9) years. Individuals with the AA genotype showed higher total fat and monounsaturated fatty acid (MUFA) intake (standardized β = 0.110 and 0.087, p = 0.01 and 0.05, respectively) compared with the GG and GA genotypes. For metabolic phenotypes, the AA genotype of rs1761667 had a lower blood pressure compared with the GG genotype (standardized β = -0.123, p = 0.02). Our results suggested that the AA genotype of rs1761667 in the CD36 gene was associated with higher intake of total fat and MUFA, and lower risk of hypertension in a Japanese population.

Original languageEnglish
JournalBritish Journal of Nutrition
DOIs
Publication statusPublished - 01-01-2019

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Monounsaturated Fatty Acids
Blood Pressure
Hypertension
Population
Genes
Genotype
Dietary Fats
Fats
Phenotype
Food
Energy Intake
Antihypertensive Agents
Japan
Cross-Sectional Studies

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Fujii, Ryosuke ; Hishida, Asahi ; Suzuki, Koji ; Imaeda, Nahomi ; Goto, Chiho ; Hamajima, Nobuyuki ; Wakai, Kenji ; Kondo, Takaaki. / CD36 gene polymorphism (rs1761667) is associated with dietary monounsaturated fatty acid intake and hypertension in a Japanese population. In: British Journal of Nutrition. 2019.
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CD36 gene polymorphism (rs1761667) is associated with dietary monounsaturated fatty acid intake and hypertension in a Japanese population. / Fujii, Ryosuke; Hishida, Asahi; Suzuki, Koji; Imaeda, Nahomi; Goto, Chiho; Hamajima, Nobuyuki; Wakai, Kenji; Kondo, Takaaki.

In: British Journal of Nutrition, 01.01.2019.

Research output: Contribution to journalArticle

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T1 - CD36 gene polymorphism (rs1761667) is associated with dietary monounsaturated fatty acid intake and hypertension in a Japanese population

AU - Fujii, Ryosuke

AU - Hishida, Asahi

AU - Suzuki, Koji

AU - Imaeda, Nahomi

AU - Goto, Chiho

AU - Hamajima, Nobuyuki

AU - Wakai, Kenji

AU - Kondo, Takaaki

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