TY - JOUR
T1 - CD40/CD40 ligand interactions in immune responses and pulmonary immunity.
AU - Kawabe, Tsutomu
AU - Matsushima, Miyoko
AU - Hashimoto, Naozumi
AU - Imaizumi, Kazuyoshi
AU - Hasegawa, Yoshinori
PY - 2011/8
Y1 - 2011/8
N2 - The CD40 ligand/CD40 pathway is widely recognized for its prominent role in immune regulation and homeostasis. CD40, a member of the tumor necrosis factor receptor family, is expressed by antigen-presenting cells, as well as non-immune cells and tumors. The engagement of the CD40 and CD40 ligands, which are transiently expressed on T cells and other non-immune cells under inflammatory conditions, regulates a wide spectrum of molecular and cellular processes, including the initiation and progression of cellular and humoral adaptive immunity. Based on recent research findings, the engagement of the CD40 with a deregulated amount of CD40 ligand has been implicated in a number of inflammatory diseases. We will discuss the involvement of the CD40 ligand/CD40 interaction in the pathophysiology of inflammatory diseases, including autoimmune diseases, atherothrombosis, cancer, and respiratory diseases.
AB - The CD40 ligand/CD40 pathway is widely recognized for its prominent role in immune regulation and homeostasis. CD40, a member of the tumor necrosis factor receptor family, is expressed by antigen-presenting cells, as well as non-immune cells and tumors. The engagement of the CD40 and CD40 ligands, which are transiently expressed on T cells and other non-immune cells under inflammatory conditions, regulates a wide spectrum of molecular and cellular processes, including the initiation and progression of cellular and humoral adaptive immunity. Based on recent research findings, the engagement of the CD40 with a deregulated amount of CD40 ligand has been implicated in a number of inflammatory diseases. We will discuss the involvement of the CD40 ligand/CD40 interaction in the pathophysiology of inflammatory diseases, including autoimmune diseases, atherothrombosis, cancer, and respiratory diseases.
UR - http://www.scopus.com/inward/record.url?scp=80053644234&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80053644234&partnerID=8YFLogxK
M3 - Review article
C2 - 21928689
AN - SCOPUS:80053644234
SN - 0027-7622
VL - 73
SP - 69
EP - 78
JO - Nagoya journal of medical science
JF - Nagoya journal of medical science
IS - 3-4
ER -
