CD40/CD40 ligand interactions in immune responses and pulmonary immunity.

Tsutomu Kawabe, Miyoko Matsushima, Naozumi Hashimoto, Kazuyoshi Imaizumi, Yoshinori Hasegawa

Research output: Contribution to journalReview articlepeer-review

49 Citations (Scopus)


The CD40 ligand/CD40 pathway is widely recognized for its prominent role in immune regulation and homeostasis. CD40, a member of the tumor necrosis factor receptor family, is expressed by antigen-presenting cells, as well as non-immune cells and tumors. The engagement of the CD40 and CD40 ligands, which are transiently expressed on T cells and other non-immune cells under inflammatory conditions, regulates a wide spectrum of molecular and cellular processes, including the initiation and progression of cellular and humoral adaptive immunity. Based on recent research findings, the engagement of the CD40 with a deregulated amount of CD40 ligand has been implicated in a number of inflammatory diseases. We will discuss the involvement of the CD40 ligand/CD40 interaction in the pathophysiology of inflammatory diseases, including autoimmune diseases, atherothrombosis, cancer, and respiratory diseases.

Original languageEnglish
Pages (from-to)69-78
Number of pages10
JournalNagoya journal of medical science
Issue number3-4
Publication statusPublished - 01-08-2011

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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