CD9 gene variations are not associated with female infertility in humans

Sachie Nishiyama, Taro Kishi, Takema Kato, MacHiko Suzuki, Haruki Nishizawa, Kanako Pryor-Koishi, Tomio Sawada, Yukio Nishiyama, Nakao Iwata, Yasuhiro Udagawa, Hiroki Kurahashi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background/Aims: To determine whether genetic alterations in the CD9 gene are associated with female infertility in humans. Methods: We sequenced the entire coding region of this gene in 86 Japanese women with unexplained infertility and further conducted a case-control study of six tagging single nucleotide polymorphisms (SNPs) in this gene using an additional 164 samples obtained from a fertile control group. Results: No disease-causing mutation in the CD9 gene was evident in these samples and no significant association between the tagging SNPs and the studied cohort was identified. Conclusions: Our findings do not support the hypothesis that genetic alterations of the CD9 gene cause female infertility in humans.

Original languageEnglish
Pages (from-to)116-121
Number of pages6
JournalGynecologic and Obstetric Investigation
Volume69
Issue number2
DOIs
Publication statusPublished - 01-03-2010

Fingerprint

Female Infertility
Genes
Single Nucleotide Polymorphism
Infertility
Case-Control Studies
Control Groups
Mutation

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Nishiyama, Sachie ; Kishi, Taro ; Kato, Takema ; Suzuki, MacHiko ; Nishizawa, Haruki ; Pryor-Koishi, Kanako ; Sawada, Tomio ; Nishiyama, Yukio ; Iwata, Nakao ; Udagawa, Yasuhiro ; Kurahashi, Hiroki. / CD9 gene variations are not associated with female infertility in humans. In: Gynecologic and Obstetric Investigation. 2010 ; Vol. 69, No. 2. pp. 116-121.
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Nishiyama, S, Kishi, T, Kato, T, Suzuki, M, Nishizawa, H, Pryor-Koishi, K, Sawada, T, Nishiyama, Y, Iwata, N, Udagawa, Y & Kurahashi, H 2010, 'CD9 gene variations are not associated with female infertility in humans', Gynecologic and Obstetric Investigation, vol. 69, no. 2, pp. 116-121. https://doi.org/10.1159/000262451

CD9 gene variations are not associated with female infertility in humans. / Nishiyama, Sachie; Kishi, Taro; Kato, Takema; Suzuki, MacHiko; Nishizawa, Haruki; Pryor-Koishi, Kanako; Sawada, Tomio; Nishiyama, Yukio; Iwata, Nakao; Udagawa, Yasuhiro; Kurahashi, Hiroki.

In: Gynecologic and Obstetric Investigation, Vol. 69, No. 2, 01.03.2010, p. 116-121.

Research output: Contribution to journalArticle

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AU - Kishi, Taro

AU - Kato, Takema

AU - Suzuki, MacHiko

AU - Nishizawa, Haruki

AU - Pryor-Koishi, Kanako

AU - Sawada, Tomio

AU - Nishiyama, Yukio

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AU - Udagawa, Yasuhiro

AU - Kurahashi, Hiroki

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