CD9 gene variations are not associated with female infertility in humans

Sachie Nishiyama; Taro Kishi; Takema Kato; MacHiko Suzuki; Haruki Nishizawa; Kanako Pryor-Koishi; Tomio Sawada; Yukio Nishiyama; Nakao Iwata; Yasuhiro Udagawa; Hiroki Kurahashi

doi:10.1159/000262451

CD9 gene variations are not associated with female infertility in humans

Sachie Nishiyama, Taro Kishi, Takema Kato, MacHiko Suzuki, Haruki Nishizawa, Kanako Pryor-Koishi, Tomio Sawada, Yukio Nishiyama, Nakao Iwata, Yasuhiro Udagawa, Hiroki Kurahashi

visiting faculty

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Background/Aims: To determine whether genetic alterations in the CD9 gene are associated with female infertility in humans. Methods: We sequenced the entire coding region of this gene in 86 Japanese women with unexplained infertility and further conducted a case-control study of six tagging single nucleotide polymorphisms (SNPs) in this gene using an additional 164 samples obtained from a fertile control group. Results: No disease-causing mutation in the CD9 gene was evident in these samples and no significant association between the tagging SNPs and the studied cohort was identified. Conclusions: Our findings do not support the hypothesis that genetic alterations of the CD9 gene cause female infertility in humans.

Original language	English
Pages (from-to)	116-121
Number of pages	6
Journal	Gynecologic and Obstetric Investigation
Volume	69
Issue number	2
DOIs	https://doi.org/10.1159/000262451
Publication status	Published - 03-2010

All Science Journal Classification (ASJC) codes

Reproductive Medicine
Obstetrics and Gynaecology

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10.1159/000262451

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title = "CD9 gene variations are not associated with female infertility in humans",

abstract = "Background/Aims: To determine whether genetic alterations in the CD9 gene are associated with female infertility in humans. Methods: We sequenced the entire coding region of this gene in 86 Japanese women with unexplained infertility and further conducted a case-control study of six tagging single nucleotide polymorphisms (SNPs) in this gene using an additional 164 samples obtained from a fertile control group. Results: No disease-causing mutation in the CD9 gene was evident in these samples and no significant association between the tagging SNPs and the studied cohort was identified. Conclusions: Our findings do not support the hypothesis that genetic alterations of the CD9 gene cause female infertility in humans.",

keywords = "CD9, Fertilization, Infertility, Sperm-oocyte fusion",

author = "Sachie Nishiyama and Taro Kishi and Takema Kato and MacHiko Suzuki and Haruki Nishizawa and Kanako Pryor-Koishi and Tomio Sawada and Yukio Nishiyama and Nakao Iwata and Yasuhiro Udagawa and Hiroki Kurahashi",

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doi = "10.1159/000262451",

language = "English",

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TY - JOUR

T1 - CD9 gene variations are not associated with female infertility in humans

AU - Nishiyama, Sachie

AU - Kishi, Taro

AU - Kato, Takema

AU - Suzuki, MacHiko

AU - Nishizawa, Haruki

AU - Pryor-Koishi, Kanako

AU - Sawada, Tomio

AU - Nishiyama, Yukio

AU - Iwata, Nakao

AU - Udagawa, Yasuhiro

AU - Kurahashi, Hiroki

PY - 2010/3

Y1 - 2010/3

N2 - Background/Aims: To determine whether genetic alterations in the CD9 gene are associated with female infertility in humans. Methods: We sequenced the entire coding region of this gene in 86 Japanese women with unexplained infertility and further conducted a case-control study of six tagging single nucleotide polymorphisms (SNPs) in this gene using an additional 164 samples obtained from a fertile control group. Results: No disease-causing mutation in the CD9 gene was evident in these samples and no significant association between the tagging SNPs and the studied cohort was identified. Conclusions: Our findings do not support the hypothesis that genetic alterations of the CD9 gene cause female infertility in humans.

AB - Background/Aims: To determine whether genetic alterations in the CD9 gene are associated with female infertility in humans. Methods: We sequenced the entire coding region of this gene in 86 Japanese women with unexplained infertility and further conducted a case-control study of six tagging single nucleotide polymorphisms (SNPs) in this gene using an additional 164 samples obtained from a fertile control group. Results: No disease-causing mutation in the CD9 gene was evident in these samples and no significant association between the tagging SNPs and the studied cohort was identified. Conclusions: Our findings do not support the hypothesis that genetic alterations of the CD9 gene cause female infertility in humans.

KW - CD9

KW - Fertilization

KW - Infertility

KW - Sperm-oocyte fusion

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JO - Gynecologic and Obstetric Investigation

JF - Gynecologic and Obstetric Investigation

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ER -

CD9 gene variations are not associated with female infertility in humans

Abstract

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