CD98 is a promising prognostic biomarker in biliary tract cancer

Kyoichi Kaira; Yutaka Sunose; Noboru Oriuchi; Yoshikatsu Kanai; Izumi Takeyoshi

doi:10.1016/S1499-3872(14)60278-2

CD98 is a promising prognostic biomarker in biliary tract cancer

Kyoichi Kaira
, Yutaka Sunose
, Noboru Oriuchi
, Yoshikatsu Kanai
, Izumi Takeyoshi

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

CD98 has been described to play a crucial role in tumor progression and survival. However, the role of CD98 in biliary tract cancer remains unclear. We found that 36.7% of all patients with biliary tract cancer had a high CD98 expression. Statistical analysis using Spearman's rank correlation showed that CD98 was significantly correlated with L-type amino acid transporter 1 (LAT1, r=0.562, P<0.001), Ki-67 (r=0.230, P=0.006) and CD34 (r=0.290, P=0.005). Multivariate analysis confirmed that a high CD98 expression was an independent prognostic factor for predicting poor outcome. CD98 is closely associated with tumor growth, biological aggressiveness, and survival of patients. With these data we proposed that CD98 expression is necessary for the development and pathogenesis of biliary tract cancer.

Original language	English
Pages (from-to)	654-657
Number of pages	4
Journal	Hepatobiliary and Pancreatic Diseases International
Volume	13
Issue number	6
DOIs	https://doi.org/10.1016/S1499-3872(14)60278-2
Publication status	Published - 15-12-2014
Externally published	Yes

All Science Journal Classification (ASJC) codes

Hepatology
Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S1499-3872(14)60278-2

Cite this

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title = "CD98 is a promising prognostic biomarker in biliary tract cancer",

abstract = "CD98 has been described to play a crucial role in tumor progression and survival. However, the role of CD98 in biliary tract cancer remains unclear. We found that 36.7\% of all patients with biliary tract cancer had a high CD98 expression. Statistical analysis using Spearman's rank correlation showed that CD98 was significantly correlated with L-type amino acid transporter 1 (LAT1, r=0.562, P<0.001), Ki-67 (r=0.230, P=0.006) and CD34 (r=0.290, P=0.005). Multivariate analysis confirmed that a high CD98 expression was an independent prognostic factor for predicting poor outcome. CD98 is closely associated with tumor growth, biological aggressiveness, and survival of patients. With these data we proposed that CD98 expression is necessary for the development and pathogenesis of biliary tract cancer.",

keywords = "amino acid transporter, biliary tract cancer, CD98, prognostic factor",

author = "Kyoichi Kaira and Yutaka Sunose and Noboru Oriuchi and Yoshikatsu Kanai and Izumi Takeyoshi",

note = "Publisher Copyright: {\textcopyright} 2014 The Editorial Board of Hepatobiliary \& Pancreatic Diseases International.",

year = "2014",

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TY - JOUR

T1 - CD98 is a promising prognostic biomarker in biliary tract cancer

AU - Kaira, Kyoichi

AU - Sunose, Yutaka

AU - Oriuchi, Noboru

AU - Kanai, Yoshikatsu

AU - Takeyoshi, Izumi

PY - 2014/12/15

Y1 - 2014/12/15

N2 - CD98 has been described to play a crucial role in tumor progression and survival. However, the role of CD98 in biliary tract cancer remains unclear. We found that 36.7% of all patients with biliary tract cancer had a high CD98 expression. Statistical analysis using Spearman's rank correlation showed that CD98 was significantly correlated with L-type amino acid transporter 1 (LAT1, r=0.562, P<0.001), Ki-67 (r=0.230, P=0.006) and CD34 (r=0.290, P=0.005). Multivariate analysis confirmed that a high CD98 expression was an independent prognostic factor for predicting poor outcome. CD98 is closely associated with tumor growth, biological aggressiveness, and survival of patients. With these data we proposed that CD98 expression is necessary for the development and pathogenesis of biliary tract cancer.

AB - CD98 has been described to play a crucial role in tumor progression and survival. However, the role of CD98 in biliary tract cancer remains unclear. We found that 36.7% of all patients with biliary tract cancer had a high CD98 expression. Statistical analysis using Spearman's rank correlation showed that CD98 was significantly correlated with L-type amino acid transporter 1 (LAT1, r=0.562, P<0.001), Ki-67 (r=0.230, P=0.006) and CD34 (r=0.290, P=0.005). Multivariate analysis confirmed that a high CD98 expression was an independent prognostic factor for predicting poor outcome. CD98 is closely associated with tumor growth, biological aggressiveness, and survival of patients. With these data we proposed that CD98 expression is necessary for the development and pathogenesis of biliary tract cancer.

KW - amino acid transporter

KW - biliary tract cancer

KW - CD98

KW - prognostic factor

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UR - https://www.scopus.com/pages/publications/84941883972#tab=citedBy

U2 - 10.1016/S1499-3872(14)60278-2

DO - 10.1016/S1499-3872(14)60278-2

M3 - Article

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AN - SCOPUS:84941883972

SN - 1499-3872

VL - 13

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JO - Hepatobiliary and Pancreatic Diseases International

JF - Hepatobiliary and Pancreatic Diseases International

IS - 6

ER -

CD98 is a promising prognostic biomarker in biliary tract cancer

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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