Cefaclor, cefprozil, and loracarbef

David L. Paterson, Yohei Doi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cefaclor, cefprozil, and loracarbef are orally administered second-generation cephalosporins. Cefaclor is similar in many aspects to cephalexin, but differs by being more active in vitro against a number of Gramnegative bacteria (Bill and Washington, 1977). Cefprozil has sometimes been described as a third-generation cephalosporin, but its spectrum of activity is only slightly wider than that of cefaclor (Chin and Neu, 1987; Eliopoulos et al., 1987). Loracarbef is structurally similar to cefaclor but has a carbon at position 1 instead of a sulfur. It has similar in vitro activity to cefaclor, with some minor enhancement against some Gram-negative bacteria. Because loracarbef is no longer available in the USA and most other countries, discussion in this chapter focuses on cefaclor and cefprozil. The chemical structures of cefaclor, cefprozil, and loracarbef are shown in Figures 21.1, 21.2, and 21.3, respectively.

Original languageEnglish
Title of host publicationKucers the Use of Antibiotics
Subtitle of host publicationA Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs, Seventh Edition
PublisherCRC Press
Pages376-382
Number of pages7
ISBN (Electronic)9781498747967
ISBN (Print)9781498747950
DOIs
Publication statusPublished - 01-01-2017
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Paterson, D. L., & Doi, Y. (2017). Cefaclor, cefprozil, and loracarbef. In Kucers the Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs, Seventh Edition (pp. 376-382). CRC Press. https://doi.org/10.1201/9781315152110