Ceftazidime-avibactam is superior to other treatment regimens against carbapenem-resistant Klebsiella pneumoniae bacteremia

Ryan K. Shields; M. Hong Nguyen; Liang Chen; Ellen G. Press; Brian A. Potoski; Rachel V. Marini; Yohei Doi; Barry N. Kreiswirth; Cornelius J. Clancy

doi:10.1128/AAC.00883-17

Ceftazidime-avibactam is superior to other treatment regimens against carbapenem-resistant Klebsiella pneumoniae bacteremia

Ryan K. Shields
, M. Hong Nguyen
, Liang Chen
, Ellen G. Press
, Brian A. Potoski
, Rachel V. Marini
, Yohei Doi
, Barry N. Kreiswirth
, Cornelius J. Clancy

Research output: Contribution to journal › Article › peer-review

431 Citations (Scopus)

Abstract

There are no data comparing outcomes of patients treated with ceftazidime-avibactam versus comparators for carbapenem-resistant Enterobacteriaceae infections. At our center, ceftazidime-avibactam treatment of carbapenem-resistant Klebsiella pneumoniae bacteremia was associated with higher rates of clinical success (P = 0.006) and survival (P = 0.01) than other regimens. Across treatment groups, there were no differences in underlying diseases, severity of illness, source of bacteremia, or strain characteristics (97% produced K. pneumoniae carbapenemase). Aminoglycoside- and colistin-containing regimens were associated with increased rates of nephrotoxicity (P = 0.002).

Original language	English
Article number	e00883
Journal	Antimicrobial agents and chemotherapy
Volume	61
Issue number	8
DOIs	https://doi.org/10.1128/AAC.00883-17
Publication status	Published - 08-2017
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.00883-17

Cite this

@article{8c1dfcfc11444e4e95cc15caa493adea,

title = "Ceftazidime-avibactam is superior to other treatment regimens against carbapenem-resistant Klebsiella pneumoniae bacteremia",

abstract = "There are no data comparing outcomes of patients treated with ceftazidime-avibactam versus comparators for carbapenem-resistant Enterobacteriaceae infections. At our center, ceftazidime-avibactam treatment of carbapenem-resistant Klebsiella pneumoniae bacteremia was associated with higher rates of clinical success (P = 0.006) and survival (P = 0.01) than other regimens. Across treatment groups, there were no differences in underlying diseases, severity of illness, source of bacteremia, or strain characteristics (97\% produced K. pneumoniae carbapenemase). Aminoglycoside- and colistin-containing regimens were associated with increased rates of nephrotoxicity (P = 0.002).",

keywords = "Bacteremia, Carbapenem-resistant Enterobacteriaceae, Ceftazidime-avibactam, Clinical success, Klebsiella pneumoniae, Klebsiella pneumoniae carbapenemase",

author = "Shields, \{Ryan K.\} and Nguyen, \{M. Hong\} and Liang Chen and Press, \{Ellen G.\} and Potoski, \{Brian A.\} and Marini, \{Rachel V.\} and Yohei Doi and Kreiswirth, \{Barry N.\} and Clancy, \{Cornelius J.\}",

year = "2017",

month = aug,

doi = "10.1128/AAC.00883-17",

language = "English",

volume = "61",

journal = "Antimicrobial agents and chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "8",

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T1 - Ceftazidime-avibactam is superior to other treatment regimens against carbapenem-resistant Klebsiella pneumoniae bacteremia

AU - Shields, Ryan K.

AU - Nguyen, M. Hong

AU - Chen, Liang

AU - Press, Ellen G.

AU - Potoski, Brian A.

AU - Marini, Rachel V.

AU - Doi, Yohei

AU - Kreiswirth, Barry N.

AU - Clancy, Cornelius J.

PY - 2017/8

Y1 - 2017/8

N2 - There are no data comparing outcomes of patients treated with ceftazidime-avibactam versus comparators for carbapenem-resistant Enterobacteriaceae infections. At our center, ceftazidime-avibactam treatment of carbapenem-resistant Klebsiella pneumoniae bacteremia was associated with higher rates of clinical success (P = 0.006) and survival (P = 0.01) than other regimens. Across treatment groups, there were no differences in underlying diseases, severity of illness, source of bacteremia, or strain characteristics (97% produced K. pneumoniae carbapenemase). Aminoglycoside- and colistin-containing regimens were associated with increased rates of nephrotoxicity (P = 0.002).

AB - There are no data comparing outcomes of patients treated with ceftazidime-avibactam versus comparators for carbapenem-resistant Enterobacteriaceae infections. At our center, ceftazidime-avibactam treatment of carbapenem-resistant Klebsiella pneumoniae bacteremia was associated with higher rates of clinical success (P = 0.006) and survival (P = 0.01) than other regimens. Across treatment groups, there were no differences in underlying diseases, severity of illness, source of bacteremia, or strain characteristics (97% produced K. pneumoniae carbapenemase). Aminoglycoside- and colistin-containing regimens were associated with increased rates of nephrotoxicity (P = 0.002).

KW - Bacteremia

KW - Carbapenem-resistant Enterobacteriaceae

KW - Ceftazidime-avibactam

KW - Clinical success

KW - Klebsiella pneumoniae

KW - Klebsiella pneumoniae carbapenemase

UR - https://www.scopus.com/pages/publications/85026380424

UR - https://www.scopus.com/pages/publications/85026380424#tab=citedBy

U2 - 10.1128/AAC.00883-17

DO - 10.1128/AAC.00883-17

M3 - Article

C2 - 28559250

AN - SCOPUS:85026380424

SN - 0066-4804

VL - 61

JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

IS - 8

M1 - e00883

ER -

Ceftazidime-avibactam is superior to other treatment regimens against carbapenem-resistant Klebsiella pneumoniae bacteremia

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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