Cell adhesion molecules in human embryo implantation

Michiko N. Fukuda, Kazuhiro Sugihara

Research output: Contribution to journalReview articlepeer-review

25 Citations (Scopus)


The process of human embryo implantation is mediated not only by evolutionarily conserved mechanisms, but also by a mechanism unique to humans. Evidence suggests that the cell adhesion molecules, L-selectin and trophinin, play a unique role in human embryo implantation. Here, we describe the dual roles of mucin carbohydrate ligand for L-selectin and trophinin protein and of the trophinin-associated proteins bystin and tastin. We then describe trophinin-mediated signal transduction in trophectoderm cells and endometrial epithelial cells. This review also covers cadherin and integrin in human embryo implantation.

Original languageEnglish
Pages (from-to)247-258
Number of pages12
JournalSheng li xue bao : [Acta physiologica Sinica]
Issue number3
Publication statusPublished - 25-06-2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine


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