Cell adhesive activity of two animal lectins through different recognition mechanisms

Yasuhiro Ozeki, Taei Matsui, Koiti Titani

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Cell adhesive activity of two animal lectins. frog (Rama catesbeiana) S-type 14K lectin and echinoidin (a C-type lectin from sea urchin plasma), was studied with human rhabdomyosarcoma (RD) cells. RD cells attached to and spread on plastic plates coatce with each lectin. Cell adhesion by the frog lectin was completely inhibited by the addition of lactose or asialofetuin glycopeptide. Echinoidin-induced cell adhesion was only inhibited by peptide GRGDS. Since echinoidin is known to contain an RGD-sequence, our results clearly indicate that this sequence is active as the cell adhesive signal. These results suggest that some of the animal lectins may function as a cell adhesive molecule rather than using the carbohydrate-recognition mechanism.

Original languageEnglish
Pages (from-to)145-147
Number of pages3
JournalFEBS Letters
Volume289
Issue number2
DOIs
Publication statusPublished - 09-09-1991

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Fingerprint Dive into the research topics of 'Cell adhesive activity of two animal lectins through different recognition mechanisms'. Together they form a unique fingerprint.

Cite this