TY - JOUR
T1 - Cell biology limb patterning
AU - Schaller, Scott A.
AU - Li, Shaoguang
AU - Ngo-Muller, Valerie
AU - Han, Man Jong
AU - Omi, Minoru
AU - Anderson, Rosalie
AU - Muneoka, Ken
PY - 2001/1/1
Y1 - 2001/1/1
N2 - Of vertebrate organ systems, the developing limb has been especially well characterized. Morphological studies have yielded a wealth of information describing limb outgrowth and have allowed for the identification of a multitude of important factors. In terms of the latter, key signaling pathways are known to control numerous aspects of limb development, including establishment of the early limb field, determination of limb identity, elongation of the limb bud, specification of digit pattern, and sculpting of the digits. Modification of underlying signaling pathways can thus result in dramatic alterations of the limb phenotype, accounting for many of the diverse limb patterns observed in nature. Given this, it is clear that signaling pathways regulate the highly orchestrated and tightly controlled sequence of cellular events necessary for limb outgrowth; however, exactly how molecular signals interface with the cell biology of limb development remains largely a mystery. In this review we first provide an overview of a number of the morphogenetic signaling pathways that have been identified in the developing limb and then review how a subset of these signals are known to modify cell behaviors important for limb outgrowth. (C) 2001 Academic Press.
AB - Of vertebrate organ systems, the developing limb has been especially well characterized. Morphological studies have yielded a wealth of information describing limb outgrowth and have allowed for the identification of a multitude of important factors. In terms of the latter, key signaling pathways are known to control numerous aspects of limb development, including establishment of the early limb field, determination of limb identity, elongation of the limb bud, specification of digit pattern, and sculpting of the digits. Modification of underlying signaling pathways can thus result in dramatic alterations of the limb phenotype, accounting for many of the diverse limb patterns observed in nature. Given this, it is clear that signaling pathways regulate the highly orchestrated and tightly controlled sequence of cellular events necessary for limb outgrowth; however, exactly how molecular signals interface with the cell biology of limb development remains largely a mystery. In this review we first provide an overview of a number of the morphogenetic signaling pathways that have been identified in the developing limb and then review how a subset of these signals are known to modify cell behaviors important for limb outgrowth. (C) 2001 Academic Press.
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U2 - 10.1016/S0074-7696(01)03014-5
DO - 10.1016/S0074-7696(01)03014-5
M3 - Article
C2 - 11131524
AN - SCOPUS:0035210026
VL - 203
SP - 483
EP - 517
JO - International Review of Cell and Molecular Biology
JF - International Review of Cell and Molecular Biology
SN - 1937-6448
ER -