Cell culture biochemical IC chip with cell-level biocompatibility

Yoshinori Inoue; Koji Ikuta

doi:10.1109/MEMSYS.2012.6170304

Cell culture biochemical IC chip with cell-level biocompatibility

Yoshinori Inoue, Koji Ikuta

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Citations (Scopus)

Abstract

We have developed a new Biochemical IC (integrated circuit) chip capable of cell culture with 3D capillaries fabricated by microstereolithography. This chip set realizes a real total system from biological synthesis to biochemical analysis. Unlike conventional μ-TAS approach, our biochemical IC chip-set has whole functions such as a micro pump, an active valve and an optical monitor for real time monitoring and control. However, since conventional photo curable polymer is not biocompatible, this fundamental issue needs to be solved to realize cell culturing and further on applications. To overcome this issue, we developed a unique approach, which was high temperature heat treatment, and accomplished to fabricate the cell culture chip based on biochemical IC.

Original language	English
Title of host publication	2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012
Pages	788-791
Number of pages	4
DOIs	https://doi.org/10.1109/MEMSYS.2012.6170304
Publication status	Published - 2012
Externally published	Yes
Event	2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012 - Paris, France Duration: 29-01-2012 → 02-02-2012

Publication series

Name	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)	1084-6999

Conference

Conference	2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012
Country/Territory	France
City	Paris
Period	29-01-12 → 02-02-12

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Mechanical Engineering
Electrical and Electronic Engineering

Access to Document

10.1109/MEMSYS.2012.6170304

Cite this

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title = "Cell culture biochemical IC chip with cell-level biocompatibility",

abstract = "We have developed a new Biochemical IC (integrated circuit) chip capable of cell culture with 3D capillaries fabricated by microstereolithography. This chip set realizes a real total system from biological synthesis to biochemical analysis. Unlike conventional μ-TAS approach, our biochemical IC chip-set has whole functions such as a micro pump, an active valve and an optical monitor for real time monitoring and control. However, since conventional photo curable polymer is not biocompatible, this fundamental issue needs to be solved to realize cell culturing and further on applications. To overcome this issue, we developed a unique approach, which was high temperature heat treatment, and accomplished to fabricate the cell culture chip based on biochemical IC.",

author = "Yoshinori Inoue and Koji Ikuta",

year = "2012",

doi = "10.1109/MEMSYS.2012.6170304",

language = "English",

isbn = "9781467303248",

series = "Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)",

pages = "788--791",

booktitle = "2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012",

note = "2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012 ; Conference date: 29-01-2012 Through 02-02-2012",

}

Inoue, Y & Ikuta, K 2012, Cell culture biochemical IC chip with cell-level biocompatibility. in 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012., 6170304, Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), pp. 788-791, 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012, Paris, France, 29-01-12. https://doi.org/10.1109/MEMSYS.2012.6170304

Cell culture biochemical IC chip with cell-level biocompatibility. / Inoue, Yoshinori; Ikuta, Koji.
2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012. 2012. p. 788-791 6170304 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

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AU - Ikuta, Koji

PY - 2012

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N2 - We have developed a new Biochemical IC (integrated circuit) chip capable of cell culture with 3D capillaries fabricated by microstereolithography. This chip set realizes a real total system from biological synthesis to biochemical analysis. Unlike conventional μ-TAS approach, our biochemical IC chip-set has whole functions such as a micro pump, an active valve and an optical monitor for real time monitoring and control. However, since conventional photo curable polymer is not biocompatible, this fundamental issue needs to be solved to realize cell culturing and further on applications. To overcome this issue, we developed a unique approach, which was high temperature heat treatment, and accomplished to fabricate the cell culture chip based on biochemical IC.

AB - We have developed a new Biochemical IC (integrated circuit) chip capable of cell culture with 3D capillaries fabricated by microstereolithography. This chip set realizes a real total system from biological synthesis to biochemical analysis. Unlike conventional μ-TAS approach, our biochemical IC chip-set has whole functions such as a micro pump, an active valve and an optical monitor for real time monitoring and control. However, since conventional photo curable polymer is not biocompatible, this fundamental issue needs to be solved to realize cell culturing and further on applications. To overcome this issue, we developed a unique approach, which was high temperature heat treatment, and accomplished to fabricate the cell culture chip based on biochemical IC.

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M3 - Conference contribution

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T3 - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)

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EP - 791

BT - 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012

T2 - 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012

Y2 - 29 January 2012 through 2 February 2012

ER -

Cell culture biochemical IC chip with cell-level biocompatibility

Abstract

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Conference

All Science Journal Classification (ASJC) codes

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