Cell type-dependent effects of corticosteroid on periostin production by primary human tissue cells

T. Shoda, K. Futamura, F. Kobayashi, H. Saito, K. Matsumoto, A. Matsuda

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Overproduction of periostin, an IL-13-inducible matricellular protein, despite corticosteroid treatment is thought to be involved in the chronicity of allergic inflammation seen in corticosteroid-refractory tissue fibrosis. Therefore, we hypothesized that some tissue cells must produce periostin in a corticosteroid-insensitive manner. Here, we show that IL-4 and IL-13 each induced comparable levels of periostin production by primary normal human fibroblasts and microvascular endothelial cells derived from lung and skin. Dexamethasone, a corticosteroid, completely inhibited IL-4/13-induced, but did not affect TGF-β-induced, periostin production by fibroblasts. In contrast, dexamethasone synergistically enhanced IL-4/13-induced periostin production by microvascular endothelial cells. TGF-β did not induce periostin production by microvascular endothelial cells. Our novel findings suggest that IL-4/13-induced microvascular endothelium-derived and/or TGF-β-induced fibroblast-derived periostin might play a pivotal role in corticosteroid- refractory tissue fibrosis, leading to chronic allergic inflammation in the lung and/or skin.

Original languageEnglish
Pages (from-to)1467-1470
Number of pages4
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume68
Issue number11
DOIs
Publication statusPublished - 11-2013

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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