Central adiponectin functions to inhibit arginine vasopressin release in conscious rats

Shintaro Iwama, Yoshihisa Sugimura, Takashi Murase, Maiko Hiroi, Motomitsu Goto, Masayuki Hayashi, Hiroshi Arima, Yutaka Oiso

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The adipocyte-derived hormone adiponectin plays an important role in modulating energy homeostasis through peripheral tissues and the central nervous system. Several studies have reported that adiponectin exists in cerebrospinal fluid and that adiponectin receptors are expressed in the hypothalamus, including the paraventricular nucleus (PVN), which plays a key role in controlling pituitary hormone secretion. Furthermore, it has been reported that magnocellular arginine vasopressin (AVP) neurones within the PVN express adiponectin receptors. These findings suggest a central role of adiponectin in the modulation of neuroendocrinological functions. In the present study, we investigated the effect of centrally-administered adiponectin on AVP release in conscious rats. Intracerebroventricular (i.c.v.) administration of adiponectin significantly reduced the basal plasma AVP concentration in a dose-dependent manner, with a maximal effect being obtained 10min after administration. The plasma AVP increase in response to either hyperosmolar or hypovolaemic stimulation was also significantly attenuated by an i.c.v. injection of adiponectin. Treatment with AMP-activated protein kinase (AMPK) inhibitor compound C (100nmol, i.c.v.) partially reversed the inhibitory effects of adiponectin on AVP release. These findings suggest that central adiponectin plays an inhibitory role in the osmoregulation and baroregulation of AVP release, that the AMPK pathway is at least partly involved in the action of adiponectin, and further suggest a novel physiological or pathophysiological role for central adiponectin in water balance via inhibition of AVP release.

Original languageEnglish
Pages (from-to)753-759
Number of pages7
JournalJournal of Neuroendocrinology
Volume21
Issue number9
DOIs
Publication statusPublished - 31-08-2009
Externally publishedYes

Fingerprint

Arginine Vasopressin
Adiponectin
Adiponectin Receptors
AMP-Activated Protein Kinases
Paraventricular Hypothalamic Nucleus
Osmoregulation
Hypovolemia
Pituitary Hormones
Protein Kinase Inhibitors
Adipocytes
Hypothalamus
Cerebrospinal Fluid
Homeostasis
Central Nervous System
Hormones
Neurons
Injections
Water

All Science Journal Classification (ASJC) codes

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

Cite this

Iwama, Shintaro ; Sugimura, Yoshihisa ; Murase, Takashi ; Hiroi, Maiko ; Goto, Motomitsu ; Hayashi, Masayuki ; Arima, Hiroshi ; Oiso, Yutaka. / Central adiponectin functions to inhibit arginine vasopressin release in conscious rats. In: Journal of Neuroendocrinology. 2009 ; Vol. 21, No. 9. pp. 753-759.
@article{d63f1d63cf85448ca218c6d175c742da,
title = "Central adiponectin functions to inhibit arginine vasopressin release in conscious rats",
abstract = "The adipocyte-derived hormone adiponectin plays an important role in modulating energy homeostasis through peripheral tissues and the central nervous system. Several studies have reported that adiponectin exists in cerebrospinal fluid and that adiponectin receptors are expressed in the hypothalamus, including the paraventricular nucleus (PVN), which plays a key role in controlling pituitary hormone secretion. Furthermore, it has been reported that magnocellular arginine vasopressin (AVP) neurones within the PVN express adiponectin receptors. These findings suggest a central role of adiponectin in the modulation of neuroendocrinological functions. In the present study, we investigated the effect of centrally-administered adiponectin on AVP release in conscious rats. Intracerebroventricular (i.c.v.) administration of adiponectin significantly reduced the basal plasma AVP concentration in a dose-dependent manner, with a maximal effect being obtained 10min after administration. The plasma AVP increase in response to either hyperosmolar or hypovolaemic stimulation was also significantly attenuated by an i.c.v. injection of adiponectin. Treatment with AMP-activated protein kinase (AMPK) inhibitor compound C (100nmol, i.c.v.) partially reversed the inhibitory effects of adiponectin on AVP release. These findings suggest that central adiponectin plays an inhibitory role in the osmoregulation and baroregulation of AVP release, that the AMPK pathway is at least partly involved in the action of adiponectin, and further suggest a novel physiological or pathophysiological role for central adiponectin in water balance via inhibition of AVP release.",
author = "Shintaro Iwama and Yoshihisa Sugimura and Takashi Murase and Maiko Hiroi and Motomitsu Goto and Masayuki Hayashi and Hiroshi Arima and Yutaka Oiso",
year = "2009",
month = "8",
day = "31",
doi = "10.1111/j.1365-2826.2009.01894.x",
language = "English",
volume = "21",
pages = "753--759",
journal = "Journal of Neuroendocrinology",
issn = "0953-8194",
publisher = "Wiley-Blackwell",
number = "9",

}

Central adiponectin functions to inhibit arginine vasopressin release in conscious rats. / Iwama, Shintaro; Sugimura, Yoshihisa; Murase, Takashi; Hiroi, Maiko; Goto, Motomitsu; Hayashi, Masayuki; Arima, Hiroshi; Oiso, Yutaka.

In: Journal of Neuroendocrinology, Vol. 21, No. 9, 31.08.2009, p. 753-759.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Central adiponectin functions to inhibit arginine vasopressin release in conscious rats

AU - Iwama, Shintaro

AU - Sugimura, Yoshihisa

AU - Murase, Takashi

AU - Hiroi, Maiko

AU - Goto, Motomitsu

AU - Hayashi, Masayuki

AU - Arima, Hiroshi

AU - Oiso, Yutaka

PY - 2009/8/31

Y1 - 2009/8/31

N2 - The adipocyte-derived hormone adiponectin plays an important role in modulating energy homeostasis through peripheral tissues and the central nervous system. Several studies have reported that adiponectin exists in cerebrospinal fluid and that adiponectin receptors are expressed in the hypothalamus, including the paraventricular nucleus (PVN), which plays a key role in controlling pituitary hormone secretion. Furthermore, it has been reported that magnocellular arginine vasopressin (AVP) neurones within the PVN express adiponectin receptors. These findings suggest a central role of adiponectin in the modulation of neuroendocrinological functions. In the present study, we investigated the effect of centrally-administered adiponectin on AVP release in conscious rats. Intracerebroventricular (i.c.v.) administration of adiponectin significantly reduced the basal plasma AVP concentration in a dose-dependent manner, with a maximal effect being obtained 10min after administration. The plasma AVP increase in response to either hyperosmolar or hypovolaemic stimulation was also significantly attenuated by an i.c.v. injection of adiponectin. Treatment with AMP-activated protein kinase (AMPK) inhibitor compound C (100nmol, i.c.v.) partially reversed the inhibitory effects of adiponectin on AVP release. These findings suggest that central adiponectin plays an inhibitory role in the osmoregulation and baroregulation of AVP release, that the AMPK pathway is at least partly involved in the action of adiponectin, and further suggest a novel physiological or pathophysiological role for central adiponectin in water balance via inhibition of AVP release.

AB - The adipocyte-derived hormone adiponectin plays an important role in modulating energy homeostasis through peripheral tissues and the central nervous system. Several studies have reported that adiponectin exists in cerebrospinal fluid and that adiponectin receptors are expressed in the hypothalamus, including the paraventricular nucleus (PVN), which plays a key role in controlling pituitary hormone secretion. Furthermore, it has been reported that magnocellular arginine vasopressin (AVP) neurones within the PVN express adiponectin receptors. These findings suggest a central role of adiponectin in the modulation of neuroendocrinological functions. In the present study, we investigated the effect of centrally-administered adiponectin on AVP release in conscious rats. Intracerebroventricular (i.c.v.) administration of adiponectin significantly reduced the basal plasma AVP concentration in a dose-dependent manner, with a maximal effect being obtained 10min after administration. The plasma AVP increase in response to either hyperosmolar or hypovolaemic stimulation was also significantly attenuated by an i.c.v. injection of adiponectin. Treatment with AMP-activated protein kinase (AMPK) inhibitor compound C (100nmol, i.c.v.) partially reversed the inhibitory effects of adiponectin on AVP release. These findings suggest that central adiponectin plays an inhibitory role in the osmoregulation and baroregulation of AVP release, that the AMPK pathway is at least partly involved in the action of adiponectin, and further suggest a novel physiological or pathophysiological role for central adiponectin in water balance via inhibition of AVP release.

UR - http://www.scopus.com/inward/record.url?scp=69249147781&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69249147781&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2826.2009.01894.x

DO - 10.1111/j.1365-2826.2009.01894.x

M3 - Article

VL - 21

SP - 753

EP - 759

JO - Journal of Neuroendocrinology

JF - Journal of Neuroendocrinology

SN - 0953-8194

IS - 9

ER -