Central administration of melanocortin agonist increased insulin sensitivity in diet-induced obese rats

Ryoichi Banno, Hiroshi Arima, Masayuki Hayashi, Motomitsu Goto, Minemori Watanabe, Ikuko Sato, Nobuaki Ozaki, Hiroshi Nagasaki, Noriyuki Ozaki, Yutaka Oiso

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

In this study, we examined the effects of intracerebroventricular administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity in diet-induced obese (DIO) rats. Although MTII treatment significantly decreased food intake and body weight for 10 days, there was no significant difference in body weight between MTII and pair-fed groups. The insulin tolerance test showed that insulin sensitivity was significantly improved in the MTII group compared to the pair-fed group. Furthermore, MTII treatment increased the number of small-sized adipocytes in epididymal white adipose tissues, suggesting that MTII increased insulin sensitivity through action on the white adipose tissues in DIO rats.

Original languageEnglish
Pages (from-to)1131-1136
Number of pages6
JournalFEBS Letters
Volume581
Issue number6
DOIs
Publication statusPublished - 20-03-2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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