Central administration of melanocortin agonist increased insulin sensitivity in diet-induced obese rats

Ryoichi Banno; Hiroshi Arima; Masayuki Hayashi; Motomitsu Goto; Minemori Watanabe; Ikuko Sato; Nobuaki Ozaki; Hiroshi Nagasaki; Noriyuki Ozaki; Yutaka Oiso

doi:10.1016/j.febslet.2007.02.019

Central administration of melanocortin agonist increased insulin sensitivity in diet-induced obese rats

Ryoichi Banno, Hiroshi Arima, Masayuki Hayashi, Motomitsu Goto, Minemori Watanabe, Ikuko Sato, Nobuaki Ozaki, Hiroshi Nagasaki, Noriyuki Ozaki, Yutaka Oiso

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

In this study, we examined the effects of intracerebroventricular administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity in diet-induced obese (DIO) rats. Although MTII treatment significantly decreased food intake and body weight for 10 days, there was no significant difference in body weight between MTII and pair-fed groups. The insulin tolerance test showed that insulin sensitivity was significantly improved in the MTII group compared to the pair-fed group. Furthermore, MTII treatment increased the number of small-sized adipocytes in epididymal white adipose tissues, suggesting that MTII increased insulin sensitivity through action on the white adipose tissues in DIO rats.

Original language	English
Pages (from-to)	1131-1136
Number of pages	6
Journal	FEBS Letters
Volume	581
Issue number	6
DOIs	https://doi.org/10.1016/j.febslet.2007.02.019
Publication status	Published - 20-03-2007
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/j.febslet.2007.02.019

Cite this

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title = "Central administration of melanocortin agonist increased insulin sensitivity in diet-induced obese rats",

abstract = "In this study, we examined the effects of intracerebroventricular administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity in diet-induced obese (DIO) rats. Although MTII treatment significantly decreased food intake and body weight for 10 days, there was no significant difference in body weight between MTII and pair-fed groups. The insulin tolerance test showed that insulin sensitivity was significantly improved in the MTII group compared to the pair-fed group. Furthermore, MTII treatment increased the number of small-sized adipocytes in epididymal white adipose tissues, suggesting that MTII increased insulin sensitivity through action on the white adipose tissues in DIO rats.",

author = "Ryoichi Banno and Hiroshi Arima and Masayuki Hayashi and Motomitsu Goto and Minemori Watanabe and Ikuko Sato and Nobuaki Ozaki and Hiroshi Nagasaki and Noriyuki Ozaki and Yutaka Oiso",

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T1 - Central administration of melanocortin agonist increased insulin sensitivity in diet-induced obese rats

AU - Banno, Ryoichi

AU - Arima, Hiroshi

AU - Hayashi, Masayuki

AU - Goto, Motomitsu

AU - Watanabe, Minemori

AU - Sato, Ikuko

AU - Ozaki, Nobuaki

AU - Nagasaki, Hiroshi

AU - Ozaki, Noriyuki

AU - Oiso, Yutaka

PY - 2007/3/20

Y1 - 2007/3/20

N2 - In this study, we examined the effects of intracerebroventricular administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity in diet-induced obese (DIO) rats. Although MTII treatment significantly decreased food intake and body weight for 10 days, there was no significant difference in body weight between MTII and pair-fed groups. The insulin tolerance test showed that insulin sensitivity was significantly improved in the MTII group compared to the pair-fed group. Furthermore, MTII treatment increased the number of small-sized adipocytes in epididymal white adipose tissues, suggesting that MTII increased insulin sensitivity through action on the white adipose tissues in DIO rats.

AB - In this study, we examined the effects of intracerebroventricular administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity in diet-induced obese (DIO) rats. Although MTII treatment significantly decreased food intake and body weight for 10 days, there was no significant difference in body weight between MTII and pair-fed groups. The insulin tolerance test showed that insulin sensitivity was significantly improved in the MTII group compared to the pair-fed group. Furthermore, MTII treatment increased the number of small-sized adipocytes in epididymal white adipose tissues, suggesting that MTII increased insulin sensitivity through action on the white adipose tissues in DIO rats.

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Central administration of melanocortin agonist increased insulin sensitivity in diet-induced obese rats

Abstract

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