Central nervous system complications in human herpesvirus-6 infection

Tetsushi Yoshikawa, Yoshizo Asano

Research output: Contribution to journalReview article

107 Citations (Scopus)

Abstract

Human herpesvirus-6 (HHV-6) is the causative agent of the common childhood infectious disease, exanthem subitum. After the virus was recently isolated from humans, it was found to be closely related to human cytomegalovirus (CMV), and was thus classified within the beta subgroup of human herpesviruses. HHV-6 possesses neurotropism in vitro, and it has been suggested that primary infection can cause complications of the central nervous system (CNS), including febrile seizures and encephalitis/encephalopathy. There is also speculation that the direct invasion of the virus into the CNS may play an important role in causing these neurological complications. Moreover, there are several reports which have suggested an association between HHV-6 and a variety of neurological disorders in adults. This paper will briefly review our virological understanding of the virus, and summarize recent findings regarding HHV-6 as an etiologic agent for CNS infection. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)307-314
Number of pages8
JournalBrain and Development
Volume22
Issue number5
DOIs
Publication statusPublished - 14-08-2000

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology

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