Central neuropathic pain after surgical resection in patients with spinal intramedullary tumor

Masaya Nakamura, Osahiko Tsuji, Akio Iwanami, Takashi Tsuji, Ken Ishii, Yoshiaki Toyama, Kazuhiro Chiba, Morio Matsumoto

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Study design Retrospective case series. Objective To examine central neuropathic pain after surgical resection of intramedullary spinal cord tumor (IMSCT). Summary of background data Because of the rarity of IMSCT, there is little information about postoperative neuropathic pain after surgical resection. Methods Eighty-five of 105 patients treated surgically for IMSCT at our hospital between 2000 and 2008 completed the Neuropathic Pain Symptom Inventory (NPSI) and the short form (SF)-36 health inventory. The NPSI score was analyzed against the tumor type and the postoperative Japanese Orthopaedic Association (JOA) score for neurological symptoms. Results The mean NPSI score of the patients was 13.5. The subscore for paresthesia/dysesthesia was significantly higher than the other subscores. Analysis of the NPSI scores by tumor type revealed no significant differences among patients with ependymoma, astrocytoma, and vascular tumors. The postoperative JOA score showed a weak negative correlation with the NPSI score in patients with thoracic spinal cord tumor, and no correlation in those with cervical tumor. In the 11 patients with hemangioblastoma, intense pain was reported at the level of the tumor, although postoperative paralysis was mild. All the postoperative SF-36 subscores of our study patients were significantly lower than the national average, and a significant negative correlation was observed between the SF-36 and the NPSI subscores. Conclusion Neuropathic pain after surgical resection reduces the QOL of patients with IMSCTs, and pain severity varies with the tumor's location and histological features, the severity of paralysis, and the location of pain relative to the tumor.

Original languageEnglish
Pages (from-to)352-357
Number of pages6
JournalJournal of Orthopaedic Science
Volume17
Issue number4
DOIs
Publication statusPublished - 01-01-2012
Externally publishedYes

Fingerprint

Neuralgia
Spinal Cord Neoplasms
Equipment and Supplies
Neoplasms
Paresthesia
Pain
Paralysis
Hemangioblastoma
Ependymoma
Astrocytoma
Postoperative Pain
Orthopedics
Blood Vessels
Thorax
Retrospective Studies
Health

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine

Cite this

Nakamura, Masaya ; Tsuji, Osahiko ; Iwanami, Akio ; Tsuji, Takashi ; Ishii, Ken ; Toyama, Yoshiaki ; Chiba, Kazuhiro ; Matsumoto, Morio. / Central neuropathic pain after surgical resection in patients with spinal intramedullary tumor. In: Journal of Orthopaedic Science. 2012 ; Vol. 17, No. 4. pp. 352-357.
@article{9bdb0cf4de314a5e94f67fe6227604d5,
title = "Central neuropathic pain after surgical resection in patients with spinal intramedullary tumor",
abstract = "Study design Retrospective case series. Objective To examine central neuropathic pain after surgical resection of intramedullary spinal cord tumor (IMSCT). Summary of background data Because of the rarity of IMSCT, there is little information about postoperative neuropathic pain after surgical resection. Methods Eighty-five of 105 patients treated surgically for IMSCT at our hospital between 2000 and 2008 completed the Neuropathic Pain Symptom Inventory (NPSI) and the short form (SF)-36 health inventory. The NPSI score was analyzed against the tumor type and the postoperative Japanese Orthopaedic Association (JOA) score for neurological symptoms. Results The mean NPSI score of the patients was 13.5. The subscore for paresthesia/dysesthesia was significantly higher than the other subscores. Analysis of the NPSI scores by tumor type revealed no significant differences among patients with ependymoma, astrocytoma, and vascular tumors. The postoperative JOA score showed a weak negative correlation with the NPSI score in patients with thoracic spinal cord tumor, and no correlation in those with cervical tumor. In the 11 patients with hemangioblastoma, intense pain was reported at the level of the tumor, although postoperative paralysis was mild. All the postoperative SF-36 subscores of our study patients were significantly lower than the national average, and a significant negative correlation was observed between the SF-36 and the NPSI subscores. Conclusion Neuropathic pain after surgical resection reduces the QOL of patients with IMSCTs, and pain severity varies with the tumor's location and histological features, the severity of paralysis, and the location of pain relative to the tumor.",
author = "Masaya Nakamura and Osahiko Tsuji and Akio Iwanami and Takashi Tsuji and Ken Ishii and Yoshiaki Toyama and Kazuhiro Chiba and Morio Matsumoto",
year = "2012",
month = "1",
day = "1",
doi = "10.1007/s00776-012-0236-6",
language = "English",
volume = "17",
pages = "352--357",
journal = "Journal of Orthopaedic Science",
issn = "0949-2658",
publisher = "Springer Japan",
number = "4",

}

Nakamura, M, Tsuji, O, Iwanami, A, Tsuji, T, Ishii, K, Toyama, Y, Chiba, K & Matsumoto, M 2012, 'Central neuropathic pain after surgical resection in patients with spinal intramedullary tumor', Journal of Orthopaedic Science, vol. 17, no. 4, pp. 352-357. https://doi.org/10.1007/s00776-012-0236-6

Central neuropathic pain after surgical resection in patients with spinal intramedullary tumor. / Nakamura, Masaya; Tsuji, Osahiko; Iwanami, Akio; Tsuji, Takashi; Ishii, Ken; Toyama, Yoshiaki; Chiba, Kazuhiro; Matsumoto, Morio.

In: Journal of Orthopaedic Science, Vol. 17, No. 4, 01.01.2012, p. 352-357.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Central neuropathic pain after surgical resection in patients with spinal intramedullary tumor

AU - Nakamura, Masaya

AU - Tsuji, Osahiko

AU - Iwanami, Akio

AU - Tsuji, Takashi

AU - Ishii, Ken

AU - Toyama, Yoshiaki

AU - Chiba, Kazuhiro

AU - Matsumoto, Morio

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Study design Retrospective case series. Objective To examine central neuropathic pain after surgical resection of intramedullary spinal cord tumor (IMSCT). Summary of background data Because of the rarity of IMSCT, there is little information about postoperative neuropathic pain after surgical resection. Methods Eighty-five of 105 patients treated surgically for IMSCT at our hospital between 2000 and 2008 completed the Neuropathic Pain Symptom Inventory (NPSI) and the short form (SF)-36 health inventory. The NPSI score was analyzed against the tumor type and the postoperative Japanese Orthopaedic Association (JOA) score for neurological symptoms. Results The mean NPSI score of the patients was 13.5. The subscore for paresthesia/dysesthesia was significantly higher than the other subscores. Analysis of the NPSI scores by tumor type revealed no significant differences among patients with ependymoma, astrocytoma, and vascular tumors. The postoperative JOA score showed a weak negative correlation with the NPSI score in patients with thoracic spinal cord tumor, and no correlation in those with cervical tumor. In the 11 patients with hemangioblastoma, intense pain was reported at the level of the tumor, although postoperative paralysis was mild. All the postoperative SF-36 subscores of our study patients were significantly lower than the national average, and a significant negative correlation was observed between the SF-36 and the NPSI subscores. Conclusion Neuropathic pain after surgical resection reduces the QOL of patients with IMSCTs, and pain severity varies with the tumor's location and histological features, the severity of paralysis, and the location of pain relative to the tumor.

AB - Study design Retrospective case series. Objective To examine central neuropathic pain after surgical resection of intramedullary spinal cord tumor (IMSCT). Summary of background data Because of the rarity of IMSCT, there is little information about postoperative neuropathic pain after surgical resection. Methods Eighty-five of 105 patients treated surgically for IMSCT at our hospital between 2000 and 2008 completed the Neuropathic Pain Symptom Inventory (NPSI) and the short form (SF)-36 health inventory. The NPSI score was analyzed against the tumor type and the postoperative Japanese Orthopaedic Association (JOA) score for neurological symptoms. Results The mean NPSI score of the patients was 13.5. The subscore for paresthesia/dysesthesia was significantly higher than the other subscores. Analysis of the NPSI scores by tumor type revealed no significant differences among patients with ependymoma, astrocytoma, and vascular tumors. The postoperative JOA score showed a weak negative correlation with the NPSI score in patients with thoracic spinal cord tumor, and no correlation in those with cervical tumor. In the 11 patients with hemangioblastoma, intense pain was reported at the level of the tumor, although postoperative paralysis was mild. All the postoperative SF-36 subscores of our study patients were significantly lower than the national average, and a significant negative correlation was observed between the SF-36 and the NPSI subscores. Conclusion Neuropathic pain after surgical resection reduces the QOL of patients with IMSCTs, and pain severity varies with the tumor's location and histological features, the severity of paralysis, and the location of pain relative to the tumor.

UR - http://www.scopus.com/inward/record.url?scp=84865140647&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865140647&partnerID=8YFLogxK

U2 - 10.1007/s00776-012-0236-6

DO - 10.1007/s00776-012-0236-6

M3 - Article

C2 - 22573215

AN - SCOPUS:84865140647

VL - 17

SP - 352

EP - 357

JO - Journal of Orthopaedic Science

JF - Journal of Orthopaedic Science

SN - 0949-2658

IS - 4

ER -