TY - JOUR
T1 - Cerebello-basal ganglia connectivity fingerprints related to motor/cognitive performance in Parkinson's disease
AU - Kawabata, Kazuya
AU - Watanabe, Hirohisa
AU - Bagarinao, Epifanio
AU - Ohdake, Reiko
AU - Hara, Kazuhiro
AU - Ogura, Aya
AU - Masuda, Michihito
AU - Kato, Toshiyasu
AU - Tsuboi, Takashi
AU - Maesawa, Satoshi
AU - Katsuno, Masahisa
AU - Sobue, Gen
N1 - Funding Information:
This work was supported by Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Number JP19K17030 ; This work was also supported by Grants-in-Aid from the Research Committee of Central Nervous System Degenerative Diseases by the Ministry of Health, Labour, and Welfare and from the Integrated Research on Neuropsychiatric Disorders project carried out under the Strategic Research for Brain Sciences by the Ministry of Education, Culture, Sports, Science, and Technology of Japan (MEXT) , a Grant-in-Aid for Scientific Research from MEXT (grant number: 80569781 ), and a Grant-in-Aid for Scientific Research on Innovative Areas (Brain Protein Aging and Dementia Control) (grant number: 26117002) from MEXT.
Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/11
Y1 - 2020/11
N2 - Introduction: The role of the cerebellum in Parkinson's disease (PD) has attracted increasing attention; however, the role of functional connectivity (FC) between the basal ganglia and particular cerebellar subregions remains to be elucidated. We aimed to clarify the FC and its contribution to motor and cognitive performances in patients with PD. Methods: We included 99 patients with PD and 99 age- and sex-matched healthy controls in this study. We created a cerebellar functional parcellation by performing cerebellum-only independent component analysis. Using the functional parcellation map, we performed seed-based connectivity analysis using each region as a seed and extracted the mean correlation coefficients within the thalamus and basal ganglia, including the caudate, pallidum, putamen and subthalamic nucleus. We examined the group differences and correlations with the motor and general cognitive scores. In addition, we conducted a mediation analysis to clarify the relationship among FC, motor severity, and cognition. Results: The PD group showed decreased FC between a wide range of cerebellar subregions and the basal ganglia. Motor severity was correlated with FC between the subthalamic nucleus and posterior Crus I/II, and general cognitive performance scores correlated with FC between the caudate nucleus and medial-posterior part of the Crus I/II (p < 0.05, corrected for multiple comparisons). The cerebello-caudate network had a direct effect on cognitive performance (p = 9.0 × 10−3), although partially mediated by motor performance (p = 8.2 × 10−3). Conclusion: FC between cerebellar Crus I/II and divergent basal ganglia related to motor and cognitive performance in PD.
AB - Introduction: The role of the cerebellum in Parkinson's disease (PD) has attracted increasing attention; however, the role of functional connectivity (FC) between the basal ganglia and particular cerebellar subregions remains to be elucidated. We aimed to clarify the FC and its contribution to motor and cognitive performances in patients with PD. Methods: We included 99 patients with PD and 99 age- and sex-matched healthy controls in this study. We created a cerebellar functional parcellation by performing cerebellum-only independent component analysis. Using the functional parcellation map, we performed seed-based connectivity analysis using each region as a seed and extracted the mean correlation coefficients within the thalamus and basal ganglia, including the caudate, pallidum, putamen and subthalamic nucleus. We examined the group differences and correlations with the motor and general cognitive scores. In addition, we conducted a mediation analysis to clarify the relationship among FC, motor severity, and cognition. Results: The PD group showed decreased FC between a wide range of cerebellar subregions and the basal ganglia. Motor severity was correlated with FC between the subthalamic nucleus and posterior Crus I/II, and general cognitive performance scores correlated with FC between the caudate nucleus and medial-posterior part of the Crus I/II (p < 0.05, corrected for multiple comparisons). The cerebello-caudate network had a direct effect on cognitive performance (p = 9.0 × 10−3), although partially mediated by motor performance (p = 8.2 × 10−3). Conclusion: FC between cerebellar Crus I/II and divergent basal ganglia related to motor and cognitive performance in PD.
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U2 - 10.1016/j.parkreldis.2020.09.005
DO - 10.1016/j.parkreldis.2020.09.005
M3 - Article
C2 - 32932024
AN - SCOPUS:85090594008
VL - 80
SP - 21
EP - 27
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
SN - 1353-8020
ER -