Cerebral cortex and lung indoleamine-2,3-dioxygenase activity is increased in type-D retrovirus infected macaques

Kuniaki Saito, Andrew Lackner, Sanford P. Markey, Melvyn P. Heyes

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Increased concentrations of the neuroactive kynurenine pathway metabolites, quinolinic acid (QUIN) and kynurenic acid (KYNA), occur in the CSF of humans infected with the human immunodeficiency virus and macaques infected with retroviruses, including the D/1/California serotype. In the present study, increased activity of indoleamine-2,3-dioxygenase (IDO), the first enzyme of the kynurenine pathway, occurred in cerebral cortex and lung of macaques with clinical SAIDS. Such increases provide a mechanism to accelerate the formation of kynurenine pathway metabolites in both systemic tissues and the central nervous system.

Original languageEnglish
Pages (from-to)353-356
Number of pages4
JournalBrain Research
Volume540
Issue number1-2
DOIs
Publication statusPublished - 01-02-1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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