Cerebral cortex and lung indoleamine-2,3-dioxygenase activity is increased in type-D retrovirus infected macaques

Kuniaki Saito; Andrew Lackner; Sanford P. Markey; Melvyn P. Heyes

doi:10.1016/0006-8993(91)90536-5

Cerebral cortex and lung indoleamine-2,3-dioxygenase activity is increased in type-D retrovirus infected macaques

Kuniaki Saito, Andrew Lackner, Sanford P. Markey, Melvyn P. Heyes

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

Increased concentrations of the neuroactive kynurenine pathway metabolites, quinolinic acid (QUIN) and kynurenic acid (KYNA), occur in the CSF of humans infected with the human immunodeficiency virus and macaques infected with retroviruses, including the D/1/California serotype. In the present study, increased activity of indoleamine-2,3-dioxygenase (IDO), the first enzyme of the kynurenine pathway, occurred in cerebral cortex and lung of macaques with clinical SAIDS. Such increases provide a mechanism to accelerate the formation of kynurenine pathway metabolites in both systemic tissues and the central nervous system.

Original language	English
Pages (from-to)	353-356
Number of pages	4
Journal	Brain Research
Volume	540
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(91)90536-5
Publication status	Published - 01-02-1991
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0006-8993(91)90536-5

Cite this

@article{e06b10ff14cb453abbf7ffdc04c61823,

title = "Cerebral cortex and lung indoleamine-2,3-dioxygenase activity is increased in type-D retrovirus infected macaques",

abstract = "Increased concentrations of the neuroactive kynurenine pathway metabolites, quinolinic acid (QUIN) and kynurenic acid (KYNA), occur in the CSF of humans infected with the human immunodeficiency virus and macaques infected with retroviruses, including the D/1/California serotype. In the present study, increased activity of indoleamine-2,3-dioxygenase (IDO), the first enzyme of the kynurenine pathway, occurred in cerebral cortex and lung of macaques with clinical SAIDS. Such increases provide a mechanism to accelerate the formation of kynurenine pathway metabolites in both systemic tissues and the central nervous system.",

author = "Kuniaki Saito and Andrew Lackner and Markey, {Sanford P.} and Heyes, {Melvyn P.}",

note = "Funding Information: We appreciate the assistance of B.J. Quearry, K. Lee and M. Der. This research was supported in part by Public Health Service Grants RR00169 from the Division of Research Resources, National Institutes of Health, and AI20573 from the National Institute of Allergy and Infectious Diseases. A.L. was supported by a Public Health Service Special Emphasis Research Career Award in Laboratory Animal Science from the Division of Research Resources, RR00039.",

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language = "English",

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T1 - Cerebral cortex and lung indoleamine-2,3-dioxygenase activity is increased in type-D retrovirus infected macaques

AU - Saito, Kuniaki

AU - Lackner, Andrew

AU - Markey, Sanford P.

AU - Heyes, Melvyn P.

N1 - Funding Information: We appreciate the assistance of B.J. Quearry, K. Lee and M. Der. This research was supported in part by Public Health Service Grants RR00169 from the Division of Research Resources, National Institutes of Health, and AI20573 from the National Institute of Allergy and Infectious Diseases. A.L. was supported by a Public Health Service Special Emphasis Research Career Award in Laboratory Animal Science from the Division of Research Resources, RR00039.

PY - 1991/2/1

Y1 - 1991/2/1

N2 - Increased concentrations of the neuroactive kynurenine pathway metabolites, quinolinic acid (QUIN) and kynurenic acid (KYNA), occur in the CSF of humans infected with the human immunodeficiency virus and macaques infected with retroviruses, including the D/1/California serotype. In the present study, increased activity of indoleamine-2,3-dioxygenase (IDO), the first enzyme of the kynurenine pathway, occurred in cerebral cortex and lung of macaques with clinical SAIDS. Such increases provide a mechanism to accelerate the formation of kynurenine pathway metabolites in both systemic tissues and the central nervous system.

AB - Increased concentrations of the neuroactive kynurenine pathway metabolites, quinolinic acid (QUIN) and kynurenic acid (KYNA), occur in the CSF of humans infected with the human immunodeficiency virus and macaques infected with retroviruses, including the D/1/California serotype. In the present study, increased activity of indoleamine-2,3-dioxygenase (IDO), the first enzyme of the kynurenine pathway, occurred in cerebral cortex and lung of macaques with clinical SAIDS. Such increases provide a mechanism to accelerate the formation of kynurenine pathway metabolites in both systemic tissues and the central nervous system.

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DO - 10.1016/0006-8993(91)90536-5

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SN - 0006-8993

VL - 540

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JO - Brain Research

JF - Brain Research

IS - 1-2

ER -

Cerebral cortex and lung indoleamine-2,3-dioxygenase activity is increased in type-D retrovirus infected macaques

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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