Cerebral hemodynamics in patients with chronic obstructive carotid disease by rCBF, rCBV, and rCBV/rCBF ratio using SPECT

Hiroshi Toyama, G. Takeshita, A. Takeuchi, H. Anno, K. Ejiri, H. Maeda, K. Katada, S. Koga, N. Ishiyama, T. Kanno, N. Yamaoka

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Abstract

To evaluate cerebral hemodynamics, 21 patients with chronic occlusion or severe stenosis of the internal carotid or middle cerebral artery with normal or only lacunar infarction on x-ray CT were studied using single photon emission computed tomography (SPECT). We measured rCBV with 99mTc erythrocytes after rCBF with 133Xe, and calculated rCBV/rCBF. rCBF and rCBV of the 25 affected hemispheres were classified as (a) patients with normal rCBF →type I (n = 7) and type II (n = 3)←; (b) patients with decreased rCBF →type III (n = 6) and type IV (n = 9)←. These two groups then could be subdivided according to findings of rCBV, normal, and increased blood volumes. rCBV/rCBF increased as the cerebral perfusion pressure dropped from type I to type III. In type IV, other situations but cerebral autoregulation could be assumed. rCBV/rCBF signifies vascular mean transit time. Type III (high rCBV/rCBF) assumed as the increased OEF, misery perfusion as reported in PET. We propose rCBF, rCBV and rCBV/rCBF using SPECT can be an index for cerebral circulatory reserve.

Original languageEnglish
Pages (from-to)55-60
Number of pages6
JournalJournal of Nuclear Medicine
Volume31
Issue number1
Publication statusPublished - 01-01-1990

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All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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Toyama, H., Takeshita, G., Takeuchi, A., Anno, H., Ejiri, K., Maeda, H., Katada, K., Koga, S., Ishiyama, N., Kanno, T., & Yamaoka, N. (1990). Cerebral hemodynamics in patients with chronic obstructive carotid disease by rCBF, rCBV, and rCBV/rCBF ratio using SPECT. Journal of Nuclear Medicine, 31(1), 55-60.