Cerebral tumor with extensive rhabdoid features and a favorable prognosis

Case report

Shigeo Oba, Kazunari Yoshida, Yuichi Hirose, Eiji Ikeda, Yoichi Nakazato, Takeshi Kawase

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

This 32-year-old woman, 27 weeks pregnant, harbored a cystic mass with a solid component in the left frontal lobe. Histologically, the lesion was hypercellular and contained a diffuse sheet of eosinophilic cells of various sizes. The cells were almost round and had a few prominent, eccentrically placed, hyperchromatic nuclei of various sizes. Immunohistochemically, the tumor was reactive for vimentin, epithelial membrane antigen, cytokeratin AE1/ AE3, smooth muscle actin, and BAF47/INI-1, and negative for glial fibrillary acidic protein, neurofilament protein, S100 protein, CK7, CK20, HMB-45, MIC2, and Bcl-2. The Ki 67 labeling index was 4.2%. Comparative genomic hybridization analysis revealed aberrations of the chromosomal copy number of +7 and -10. This tumor could not be categorized according to the present World Health Organization classification. Results of staining with glial fibrillary acidic protein were not consistent with a glioma, and staining with INI-1 was inconsistent with atypical teratoid/rhabdoid tumor. The tumor was therefore designated as a "cerebral tumor with extensive rhabdoid features.".

Original languageEnglish
Pages (from-to)492-496
Number of pages5
JournalJournal of Neurosurgery
Volume111
Issue number3
DOIs
Publication statusPublished - 07-12-2009

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Glial Fibrillary Acidic Protein
Neoplasms
Staining and Labeling
Neurofilament Proteins
Mucin-1
Comparative Genomic Hybridization
S100 Proteins
Frontal Lobe
Vimentin
Keratins
Cell Size
Glioma
Chromosome Aberrations
Smooth Muscle
Actins
Typical Teratoid Rhabdoid Tumor
Atypical Teratoid Tumor

All Science Journal Classification (ASJC) codes

  • Surgery
  • Medicine(all)
  • Clinical Neurology

Cite this

Oba, Shigeo ; Yoshida, Kazunari ; Hirose, Yuichi ; Ikeda, Eiji ; Nakazato, Yoichi ; Kawase, Takeshi. / Cerebral tumor with extensive rhabdoid features and a favorable prognosis : Case report. In: Journal of Neurosurgery. 2009 ; Vol. 111, No. 3. pp. 492-496.
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Cerebral tumor with extensive rhabdoid features and a favorable prognosis : Case report. / Oba, Shigeo; Yoshida, Kazunari; Hirose, Yuichi; Ikeda, Eiji; Nakazato, Yoichi; Kawase, Takeshi.

In: Journal of Neurosurgery, Vol. 111, No. 3, 07.12.2009, p. 492-496.

Research output: Contribution to journalArticle

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AU - Oba, Shigeo

AU - Yoshida, Kazunari

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AU - Kawase, Takeshi

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