Cerebrospinal fluid apo E and apo A-I concentrations in early- and late- onset Alzheimer's disease

Hua Song, Kuniaki Saito, Mitsuru Seishima, Akio Noma, Katsuya Urakami, Kenji Nakashima

Research output: Contribution to journalArticle

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Abstract

We compared cerebrospinal fluid (CSF) apolipoprotein (apo) A-I and apo E concentrations in early- and late-onset Alzheimer's disease (EOAD (n = 11), LOAD (n = 15), respectively) with those in control subjects (n = 23). CSF apo A-I levels in both EOAD and LOAD were consistent with control subjects. However, CSF apo E levels were significantly lower in EOAD group (mean ± SD; 2.65 ± 1.69 mg/l, P < 0.05) and higher in LOAD group (5.90 ± 1.94 mg/l, P < 0.01) than those in control group (4.16 ± 1.69 mg/l). In addition, the ξ4 allele frequency was not different between EOAD and LOAD groups. Although the reason for the difference in CSF apo E concentrations between two groups is unknown, CSF apo E concentration seems to be associated with the pathogenesis of EOAD and LOAD. The rate of apo E production and/or catabolism in the brain may be different between them.

Original languageEnglish
Pages (from-to)175-178
Number of pages4
JournalNeuroscience Letters
Volume231
Issue number3
DOIs
Publication statusPublished - 15-08-1997
Externally publishedYes

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Apolipoprotein A-I
Apolipoproteins E
Cerebrospinal Fluid
Alzheimer Disease
Gene Frequency
Control Groups
Brain

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Song, Hua ; Saito, Kuniaki ; Seishima, Mitsuru ; Noma, Akio ; Urakami, Katsuya ; Nakashima, Kenji. / Cerebrospinal fluid apo E and apo A-I concentrations in early- and late- onset Alzheimer's disease. In: Neuroscience Letters. 1997 ; Vol. 231, No. 3. pp. 175-178.
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Cerebrospinal fluid apo E and apo A-I concentrations in early- and late- onset Alzheimer's disease. / Song, Hua; Saito, Kuniaki; Seishima, Mitsuru; Noma, Akio; Urakami, Katsuya; Nakashima, Kenji.

In: Neuroscience Letters, Vol. 231, No. 3, 15.08.1997, p. 175-178.

Research output: Contribution to journalArticle

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AU - Song, Hua

AU - Saito, Kuniaki

AU - Seishima, Mitsuru

AU - Noma, Akio

AU - Urakami, Katsuya

AU - Nakashima, Kenji

PY - 1997/8/15

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N2 - We compared cerebrospinal fluid (CSF) apolipoprotein (apo) A-I and apo E concentrations in early- and late-onset Alzheimer's disease (EOAD (n = 11), LOAD (n = 15), respectively) with those in control subjects (n = 23). CSF apo A-I levels in both EOAD and LOAD were consistent with control subjects. However, CSF apo E levels were significantly lower in EOAD group (mean ± SD; 2.65 ± 1.69 mg/l, P < 0.05) and higher in LOAD group (5.90 ± 1.94 mg/l, P < 0.01) than those in control group (4.16 ± 1.69 mg/l). In addition, the ξ4 allele frequency was not different between EOAD and LOAD groups. Although the reason for the difference in CSF apo E concentrations between two groups is unknown, CSF apo E concentration seems to be associated with the pathogenesis of EOAD and LOAD. The rate of apo E production and/or catabolism in the brain may be different between them.

AB - We compared cerebrospinal fluid (CSF) apolipoprotein (apo) A-I and apo E concentrations in early- and late-onset Alzheimer's disease (EOAD (n = 11), LOAD (n = 15), respectively) with those in control subjects (n = 23). CSF apo A-I levels in both EOAD and LOAD were consistent with control subjects. However, CSF apo E levels were significantly lower in EOAD group (mean ± SD; 2.65 ± 1.69 mg/l, P < 0.05) and higher in LOAD group (5.90 ± 1.94 mg/l, P < 0.01) than those in control group (4.16 ± 1.69 mg/l). In addition, the ξ4 allele frequency was not different between EOAD and LOAD groups. Although the reason for the difference in CSF apo E concentrations between two groups is unknown, CSF apo E concentration seems to be associated with the pathogenesis of EOAD and LOAD. The rate of apo E production and/or catabolism in the brain may be different between them.

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