Cerebrospinal fluid nitrite/nitrate levels in neurologic diseases

Sheldon Milstien, Naoki Sakai, Bruce J. Brew, Charles Krieger, James H. Vickers, Kuniaki Saito, Melvyn P. Heyes

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Nitric oxide has been proposed to mediate cytotoxic effects in inflammatory diseases. To investigate the possibility that overproduction of nitric oxide might play a role in the neuropathology of inflammatory and noninflammatory neurological diseases, we compared levels of the markers of nitric oxide, nitrite plus nitrate, in the CSF of controls with those in patients with various neurologic diseases, including Huntington's and Alzheimer's disease, amyotrophic lateral sclerosis, and HIV infection. We found that there were no significant increases in the CSF levels of these nitric oxide metabolites, even in patients infected with HIV or in monkeys infected with poliovirus, both of which have significantly elevated levels of the neurotoxin quinolinic acid and the marker of macrophage activation, neopterin. However, CSF quinolinic acid, neopterin, and nitrite/nitrate levels were significantly increased in a small group of patients with bacterial and viral meningitis.

Original languageEnglish
Pages (from-to)1178-1180
Number of pages3
JournalJournal of Neurochemistry
Volume63
Issue number3
Publication statusPublished - 01-09-1994
Externally publishedYes

Fingerprint

Cerebrospinal fluid
Nitrites
Nervous System Diseases
Nitrates
Cerebrospinal Fluid
Nitric Oxide
Quinolinic Acid
Neopterin
Viral Meningitis
Bacterial Meningitides
Poliovirus
Macrophage Activation
Macrophages
Huntington Disease
Neurotoxins
Amyotrophic Lateral Sclerosis
Metabolites
HIV Infections
Haplorhini
Alzheimer Disease

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Milstien, S., Sakai, N., Brew, B. J., Krieger, C., Vickers, J. H., Saito, K., & Heyes, M. P. (1994). Cerebrospinal fluid nitrite/nitrate levels in neurologic diseases. Journal of Neurochemistry, 63(3), 1178-1180.
Milstien, Sheldon ; Sakai, Naoki ; Brew, Bruce J. ; Krieger, Charles ; Vickers, James H. ; Saito, Kuniaki ; Heyes, Melvyn P. / Cerebrospinal fluid nitrite/nitrate levels in neurologic diseases. In: Journal of Neurochemistry. 1994 ; Vol. 63, No. 3. pp. 1178-1180.
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Milstien, S, Sakai, N, Brew, BJ, Krieger, C, Vickers, JH, Saito, K & Heyes, MP 1994, 'Cerebrospinal fluid nitrite/nitrate levels in neurologic diseases', Journal of Neurochemistry, vol. 63, no. 3, pp. 1178-1180.

Cerebrospinal fluid nitrite/nitrate levels in neurologic diseases. / Milstien, Sheldon; Sakai, Naoki; Brew, Bruce J.; Krieger, Charles; Vickers, James H.; Saito, Kuniaki; Heyes, Melvyn P.

In: Journal of Neurochemistry, Vol. 63, No. 3, 01.09.1994, p. 1178-1180.

Research output: Contribution to journalArticle

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Milstien S, Sakai N, Brew BJ, Krieger C, Vickers JH, Saito K et al. Cerebrospinal fluid nitrite/nitrate levels in neurologic diseases. Journal of Neurochemistry. 1994 Sep 1;63(3):1178-1180.