Change of strategies and future perspectives against hepatitis B virus recurrence after liver transplantation

Masatoshi Ishigami, Yasuhiro Ogura, Yoshiki Hirooka, Hidemi Goto

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)

Abstract

A few decades ago, liver transplantation in patients with chronic hepatitis B virus (HBV) infection was considered a relative contraindication because of the high rate of graft infections and poor prognosis. Since then, remarkable progress was introduced by using nucleos(t)ide analogues and/or hepatitis B immunoglobulin (HBIg) and liver transplantation for HBV-related disease is now becoming one of the good indication. However, high cost burden is the main problem for this combination prophylaxis for a long time use, and this issue should be emerged to be resolved. In this review, we show the progress of post anti-HBV strategies showing the history from introduction of HBIg and nucleos(t)ide analogues to recent new strategies with hepatitis B vaccine or saving or stopping protocols of HBIg, and clarify and discuss how to do for further improvement of prevention strategies with better quality.

Original languageEnglish
Pages (from-to)10290-10298
Number of pages9
JournalWorld Journal of Gastroenterology
Volume21
Issue number36
DOIs
Publication statusPublished - 28-09-2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Fingerprint Dive into the research topics of 'Change of strategies and future perspectives against hepatitis B virus recurrence after liver transplantation'. Together they form a unique fingerprint.

Cite this