Changes in ciliary neurotrophic factor content in the rat brain after continuous intracerebroventricular infusion of β-amyloid(1-40) protein

Kiyofumi Yamada, Atsumi Nitta, Tsuyoshi Saito, Jianguo Hu, Toshitaka Nabeshima

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Abstract

We have previously shown that the continuous intracerebroventricular infusion of β-amyloid(1-40) protein results in memory impairments in rats, associated with a reduction of choline acetyltransferase activity in the frontal cortex and hippocampus. In the present study, we examined whether the infusion of β-amyloid(1-40) protein affected the content of ciliary neurotrophic factor (CNTF) in the rat brain. The β-amyloid(1-40) infusion increased CNTF content in the frontal cortex, hippocampus, and the cerebellum, but decreased its content in the brain stem. These results suggest that accumulation of β-amyloid(1-40) in the brain may affect CNTF production in vivo.

Original languageEnglish
Pages (from-to)155-158
Number of pages4
JournalNeuroscience Letters
Volume201
Issue number2
DOIs
Publication statusPublished - 08-12-1995

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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