Changes in ciliary neurotrophic factor content in the rat brain after continuous intracerebroventricular infusion of β-amyloid(1-40) protein

Kiyofumi Yamada, Atsumi Nitta, Tsuyoshi Saito, Jianguo Hu, Toshitaka Nabeshima

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We have previously shown that the continuous intracerebroventricular infusion of β-amyloid(1-40) protein results in memory impairments in rats, associated with a reduction of choline acetyltransferase activity in the frontal cortex and hippocampus. In the present study, we examined whether the infusion of β-amyloid(1-40) protein affected the content of ciliary neurotrophic factor (CNTF) in the rat brain. The β-amyloid(1-40) infusion increased CNTF content in the frontal cortex, hippocampus, and the cerebellum, but decreased its content in the brain stem. These results suggest that accumulation of β-amyloid(1-40) in the brain may affect CNTF production in vivo.

Original languageEnglish
Pages (from-to)155-158
Number of pages4
JournalNeuroscience Letters
Volume201
Issue number2
DOIs
Publication statusPublished - 08-12-1995
Externally publishedYes

Fingerprint

Ciliary Neurotrophic Factor
Intraventricular Infusions
Amyloid
Brain
Frontal Lobe
Hippocampus
Proteins
Choline O-Acetyltransferase
Cerebellum
Brain Stem

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

@article{e0e5f49c3f5648ac9f8355bc148c7f84,
title = "Changes in ciliary neurotrophic factor content in the rat brain after continuous intracerebroventricular infusion of β-amyloid(1-40) protein",
abstract = "We have previously shown that the continuous intracerebroventricular infusion of β-amyloid(1-40) protein results in memory impairments in rats, associated with a reduction of choline acetyltransferase activity in the frontal cortex and hippocampus. In the present study, we examined whether the infusion of β-amyloid(1-40) protein affected the content of ciliary neurotrophic factor (CNTF) in the rat brain. The β-amyloid(1-40) infusion increased CNTF content in the frontal cortex, hippocampus, and the cerebellum, but decreased its content in the brain stem. These results suggest that accumulation of β-amyloid(1-40) in the brain may affect CNTF production in vivo.",
author = "Kiyofumi Yamada and Atsumi Nitta and Tsuyoshi Saito and Jianguo Hu and Toshitaka Nabeshima",
year = "1995",
month = "12",
day = "8",
doi = "10.1016/0304-3940(95)12161-7",
language = "English",
volume = "201",
pages = "155--158",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

Changes in ciliary neurotrophic factor content in the rat brain after continuous intracerebroventricular infusion of β-amyloid(1-40) protein. / Yamada, Kiyofumi; Nitta, Atsumi; Saito, Tsuyoshi; Hu, Jianguo; Nabeshima, Toshitaka.

In: Neuroscience Letters, Vol. 201, No. 2, 08.12.1995, p. 155-158.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Changes in ciliary neurotrophic factor content in the rat brain after continuous intracerebroventricular infusion of β-amyloid(1-40) protein

AU - Yamada, Kiyofumi

AU - Nitta, Atsumi

AU - Saito, Tsuyoshi

AU - Hu, Jianguo

AU - Nabeshima, Toshitaka

PY - 1995/12/8

Y1 - 1995/12/8

N2 - We have previously shown that the continuous intracerebroventricular infusion of β-amyloid(1-40) protein results in memory impairments in rats, associated with a reduction of choline acetyltransferase activity in the frontal cortex and hippocampus. In the present study, we examined whether the infusion of β-amyloid(1-40) protein affected the content of ciliary neurotrophic factor (CNTF) in the rat brain. The β-amyloid(1-40) infusion increased CNTF content in the frontal cortex, hippocampus, and the cerebellum, but decreased its content in the brain stem. These results suggest that accumulation of β-amyloid(1-40) in the brain may affect CNTF production in vivo.

AB - We have previously shown that the continuous intracerebroventricular infusion of β-amyloid(1-40) protein results in memory impairments in rats, associated with a reduction of choline acetyltransferase activity in the frontal cortex and hippocampus. In the present study, we examined whether the infusion of β-amyloid(1-40) protein affected the content of ciliary neurotrophic factor (CNTF) in the rat brain. The β-amyloid(1-40) infusion increased CNTF content in the frontal cortex, hippocampus, and the cerebellum, but decreased its content in the brain stem. These results suggest that accumulation of β-amyloid(1-40) in the brain may affect CNTF production in vivo.

UR - http://www.scopus.com/inward/record.url?scp=0028802698&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028802698&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(95)12161-7

DO - 10.1016/0304-3940(95)12161-7

M3 - Article

C2 - 8848241

AN - SCOPUS:0028802698

VL - 201

SP - 155

EP - 158

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2

ER -