Changes in gastric mucosal patterns seen by magnifying NBI during H. pylori eradication

Masaaki Okubo, Tomomitsu Tahara, Tomoyuki Shibata, Masakatsu Nakamura, Daisuke Yoshioka, Yoshiteru Maeda, Joh Yonemura, Takamitsu Ishizuka, Tomiyasu Arisawa, Ichiro Hirata

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Magnifying narrow-band imaging (NBI) endoscopy visualizes superficial gastric mucosal and capillary patterns. We aimed to investigate changes in gastric mucosal patterns seen by magnifying NBI endoscopy after Helicobacter pylori eradication. Methods: Gastric mucosal patterns in non-pathological gastric corpus were observed by magnifying NBI endoscopy before and 12 weeks after H. pylori eradication in thirty patients. By using paired photographs of each case, changes in NBI mucosal patterns during H. pylori eradication were judged in a consensus manner by three blinded endoscopists. Results: At 12 weeks after H. pylori eradication, 20 of 24 subjects who had been successfully treated showed remarkable changes in gastric mucosal patterns (sensitivity 83.3%, specificity 100%). In the specimens from these subjects, the patterns of enlarged or elongated pits were improved to small oval or pinhole-like round pits, and the density of fine irregular vessels was decreased. Histological assessment showed alleviation of chronic inflammation in all subjects (p < 0.0001), while such a change was not observed for four subjects showing severe gastric atrophy and intestinal metaplasia. When the subjects were divided according to the presence of severe gastric atrophy, the diagnostic efficacy of magnifying NBI for predicting the results of H. pylori eradication was excellent in subjects without severe gastric atrophy and intestinal metaplasia (sensitivity and specificity, 100%). However, no change in the NBI mucosal pattern was observed in subjects with severe gastric atrophy and intestinal metaplasia, regardless of the H. pylori eradication result. Conclusions: At least in subjects without severe gastric atrophy or intestinal metaplasia, successful H. pylori eradication treatment shows improvements in gastric mucosal patterns with the use of magnifying NBI endoscopy early after successful treatment.

Original languageEnglish
Pages (from-to)175-182
Number of pages8
JournalJournal of Gastroenterology
Volume46
Issue number2
DOIs
Publication statusPublished - 01-02-2011

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Narrow Band Imaging
Pylorus
Stomach
Helicobacter pylori
Atrophy
Metaplasia
Endoscopy
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Okubo, Masaaki ; Tahara, Tomomitsu ; Shibata, Tomoyuki ; Nakamura, Masakatsu ; Yoshioka, Daisuke ; Maeda, Yoshiteru ; Yonemura, Joh ; Ishizuka, Takamitsu ; Arisawa, Tomiyasu ; Hirata, Ichiro. / Changes in gastric mucosal patterns seen by magnifying NBI during H. pylori eradication. In: Journal of Gastroenterology. 2011 ; Vol. 46, No. 2. pp. 175-182.
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abstract = "Background: Magnifying narrow-band imaging (NBI) endoscopy visualizes superficial gastric mucosal and capillary patterns. We aimed to investigate changes in gastric mucosal patterns seen by magnifying NBI endoscopy after Helicobacter pylori eradication. Methods: Gastric mucosal patterns in non-pathological gastric corpus were observed by magnifying NBI endoscopy before and 12 weeks after H. pylori eradication in thirty patients. By using paired photographs of each case, changes in NBI mucosal patterns during H. pylori eradication were judged in a consensus manner by three blinded endoscopists. Results: At 12 weeks after H. pylori eradication, 20 of 24 subjects who had been successfully treated showed remarkable changes in gastric mucosal patterns (sensitivity 83.3{\%}, specificity 100{\%}). In the specimens from these subjects, the patterns of enlarged or elongated pits were improved to small oval or pinhole-like round pits, and the density of fine irregular vessels was decreased. Histological assessment showed alleviation of chronic inflammation in all subjects (p < 0.0001), while such a change was not observed for four subjects showing severe gastric atrophy and intestinal metaplasia. When the subjects were divided according to the presence of severe gastric atrophy, the diagnostic efficacy of magnifying NBI for predicting the results of H. pylori eradication was excellent in subjects without severe gastric atrophy and intestinal metaplasia (sensitivity and specificity, 100{\%}). However, no change in the NBI mucosal pattern was observed in subjects with severe gastric atrophy and intestinal metaplasia, regardless of the H. pylori eradication result. Conclusions: At least in subjects without severe gastric atrophy or intestinal metaplasia, successful H. pylori eradication treatment shows improvements in gastric mucosal patterns with the use of magnifying NBI endoscopy early after successful treatment.",
author = "Masaaki Okubo and Tomomitsu Tahara and Tomoyuki Shibata and Masakatsu Nakamura and Daisuke Yoshioka and Yoshiteru Maeda and Joh Yonemura and Takamitsu Ishizuka and Tomiyasu Arisawa and Ichiro Hirata",
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Okubo, M, Tahara, T, Shibata, T, Nakamura, M, Yoshioka, D, Maeda, Y, Yonemura, J, Ishizuka, T, Arisawa, T & Hirata, I 2011, 'Changes in gastric mucosal patterns seen by magnifying NBI during H. pylori eradication', Journal of Gastroenterology, vol. 46, no. 2, pp. 175-182. https://doi.org/10.1007/s00535-010-0335-0

Changes in gastric mucosal patterns seen by magnifying NBI during H. pylori eradication. / Okubo, Masaaki; Tahara, Tomomitsu; Shibata, Tomoyuki; Nakamura, Masakatsu; Yoshioka, Daisuke; Maeda, Yoshiteru; Yonemura, Joh; Ishizuka, Takamitsu; Arisawa, Tomiyasu; Hirata, Ichiro.

In: Journal of Gastroenterology, Vol. 46, No. 2, 01.02.2011, p. 175-182.

Research output: Contribution to journalArticle

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T1 - Changes in gastric mucosal patterns seen by magnifying NBI during H. pylori eradication

AU - Okubo, Masaaki

AU - Tahara, Tomomitsu

AU - Shibata, Tomoyuki

AU - Nakamura, Masakatsu

AU - Yoshioka, Daisuke

AU - Maeda, Yoshiteru

AU - Yonemura, Joh

AU - Ishizuka, Takamitsu

AU - Arisawa, Tomiyasu

AU - Hirata, Ichiro

PY - 2011/2/1

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N2 - Background: Magnifying narrow-band imaging (NBI) endoscopy visualizes superficial gastric mucosal and capillary patterns. We aimed to investigate changes in gastric mucosal patterns seen by magnifying NBI endoscopy after Helicobacter pylori eradication. Methods: Gastric mucosal patterns in non-pathological gastric corpus were observed by magnifying NBI endoscopy before and 12 weeks after H. pylori eradication in thirty patients. By using paired photographs of each case, changes in NBI mucosal patterns during H. pylori eradication were judged in a consensus manner by three blinded endoscopists. Results: At 12 weeks after H. pylori eradication, 20 of 24 subjects who had been successfully treated showed remarkable changes in gastric mucosal patterns (sensitivity 83.3%, specificity 100%). In the specimens from these subjects, the patterns of enlarged or elongated pits were improved to small oval or pinhole-like round pits, and the density of fine irregular vessels was decreased. Histological assessment showed alleviation of chronic inflammation in all subjects (p < 0.0001), while such a change was not observed for four subjects showing severe gastric atrophy and intestinal metaplasia. When the subjects were divided according to the presence of severe gastric atrophy, the diagnostic efficacy of magnifying NBI for predicting the results of H. pylori eradication was excellent in subjects without severe gastric atrophy and intestinal metaplasia (sensitivity and specificity, 100%). However, no change in the NBI mucosal pattern was observed in subjects with severe gastric atrophy and intestinal metaplasia, regardless of the H. pylori eradication result. Conclusions: At least in subjects without severe gastric atrophy or intestinal metaplasia, successful H. pylori eradication treatment shows improvements in gastric mucosal patterns with the use of magnifying NBI endoscopy early after successful treatment.

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