Changes in glial cells in Binswanger-type infarction

H. Tomimoto, I. Akiguchi, H. Wakita, J. Kimura

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Changes in glial cells were investigated immunohistochemically in the autopsy brains of patients with Binswanger-type infarction and the brains of rats with chronic cerebral hypoperfusion. Activated microglia, which are positive for MHC class II antigen, and GFAP immunoreactive astroglia were 3.1 times and 1.6 times, respectively, more numerous, in Binswanger-type infarction than in normal white matter. Chronic cerebral hypoperfusion after bilateral permanent occlusion of the carotid arteries elicited marked activation of microglia and an increase in astroglia in the medial corpus callosum after 1 day of occlusion, and these findings persisted up to 30 days after the occlusion. A decreased number of transferrin-immunoreactive oligodendroglia and rarefaction of the white matter were noted after 14 days of occlusion. These findings indicate that chronic mild ischemia may lead to rarefaction of the white matter, and that the activation of glial cells, which precedes rarefaction of the white matter, may be involved in the pathogenesis of Binswanger-type infarction.

Original languageEnglish
Pages (from-to)771-779
Number of pages9
JournalBrain and Nerve
Volume46
Issue number8
Publication statusPublished - 01-01-1994
Externally publishedYes

Fingerprint

Neuroglia
Infarction
Microglia
Astrocytes
Brain Infarction
Corpus Callosum
Histocompatibility Antigens Class II
Oligodendroglia
Transferrin
Carotid Arteries
Autopsy
Ischemia
White Matter
Brain

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Tomimoto, H., Akiguchi, I., Wakita, H., & Kimura, J. (1994). Changes in glial cells in Binswanger-type infarction. Brain and Nerve, 46(8), 771-779.
Tomimoto, H. ; Akiguchi, I. ; Wakita, H. ; Kimura, J. / Changes in glial cells in Binswanger-type infarction. In: Brain and Nerve. 1994 ; Vol. 46, No. 8. pp. 771-779.
@article{a06cd386a6f74840b2788f383bae35f7,
title = "Changes in glial cells in Binswanger-type infarction",
abstract = "Changes in glial cells were investigated immunohistochemically in the autopsy brains of patients with Binswanger-type infarction and the brains of rats with chronic cerebral hypoperfusion. Activated microglia, which are positive for MHC class II antigen, and GFAP immunoreactive astroglia were 3.1 times and 1.6 times, respectively, more numerous, in Binswanger-type infarction than in normal white matter. Chronic cerebral hypoperfusion after bilateral permanent occlusion of the carotid arteries elicited marked activation of microglia and an increase in astroglia in the medial corpus callosum after 1 day of occlusion, and these findings persisted up to 30 days after the occlusion. A decreased number of transferrin-immunoreactive oligodendroglia and rarefaction of the white matter were noted after 14 days of occlusion. These findings indicate that chronic mild ischemia may lead to rarefaction of the white matter, and that the activation of glial cells, which precedes rarefaction of the white matter, may be involved in the pathogenesis of Binswanger-type infarction.",
author = "H. Tomimoto and I. Akiguchi and H. Wakita and J. Kimura",
year = "1994",
month = "1",
day = "1",
language = "English",
volume = "46",
pages = "771--779",
journal = "Brain and Nerve",
issn = "0006-8969",
publisher = "Igaku-Shoin Ltd",
number = "8",

}

Tomimoto, H, Akiguchi, I, Wakita, H & Kimura, J 1994, 'Changes in glial cells in Binswanger-type infarction', Brain and Nerve, vol. 46, no. 8, pp. 771-779.

Changes in glial cells in Binswanger-type infarction. / Tomimoto, H.; Akiguchi, I.; Wakita, H.; Kimura, J.

In: Brain and Nerve, Vol. 46, No. 8, 01.01.1994, p. 771-779.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Changes in glial cells in Binswanger-type infarction

AU - Tomimoto, H.

AU - Akiguchi, I.

AU - Wakita, H.

AU - Kimura, J.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Changes in glial cells were investigated immunohistochemically in the autopsy brains of patients with Binswanger-type infarction and the brains of rats with chronic cerebral hypoperfusion. Activated microglia, which are positive for MHC class II antigen, and GFAP immunoreactive astroglia were 3.1 times and 1.6 times, respectively, more numerous, in Binswanger-type infarction than in normal white matter. Chronic cerebral hypoperfusion after bilateral permanent occlusion of the carotid arteries elicited marked activation of microglia and an increase in astroglia in the medial corpus callosum after 1 day of occlusion, and these findings persisted up to 30 days after the occlusion. A decreased number of transferrin-immunoreactive oligodendroglia and rarefaction of the white matter were noted after 14 days of occlusion. These findings indicate that chronic mild ischemia may lead to rarefaction of the white matter, and that the activation of glial cells, which precedes rarefaction of the white matter, may be involved in the pathogenesis of Binswanger-type infarction.

AB - Changes in glial cells were investigated immunohistochemically in the autopsy brains of patients with Binswanger-type infarction and the brains of rats with chronic cerebral hypoperfusion. Activated microglia, which are positive for MHC class II antigen, and GFAP immunoreactive astroglia were 3.1 times and 1.6 times, respectively, more numerous, in Binswanger-type infarction than in normal white matter. Chronic cerebral hypoperfusion after bilateral permanent occlusion of the carotid arteries elicited marked activation of microglia and an increase in astroglia in the medial corpus callosum after 1 day of occlusion, and these findings persisted up to 30 days after the occlusion. A decreased number of transferrin-immunoreactive oligodendroglia and rarefaction of the white matter were noted after 14 days of occlusion. These findings indicate that chronic mild ischemia may lead to rarefaction of the white matter, and that the activation of glial cells, which precedes rarefaction of the white matter, may be involved in the pathogenesis of Binswanger-type infarction.

UR - http://www.scopus.com/inward/record.url?scp=0027994312&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027994312&partnerID=8YFLogxK

M3 - Article

VL - 46

SP - 771

EP - 779

JO - Brain and Nerve

JF - Brain and Nerve

SN - 0006-8969

IS - 8

ER -

Tomimoto H, Akiguchi I, Wakita H, Kimura J. Changes in glial cells in Binswanger-type infarction. Brain and Nerve. 1994 Jan 1;46(8):771-779.