TY - JOUR
T1 - Changes in mac antibody levels before and after surgery and at the time of relapse/recurrence in mac lung disease - Can mac antibodies be an indicator of postoperative relapse/recurrence?
AU - Yamada, Katsuo
AU - Kawasumi, Yuuta
AU - Yasuda, Ayuko
AU - Seki, Yukio
AU - Adachi, Takashi
AU - Tarumi, Osamu
AU - Hayashi, Yuuta
AU - Nakagawa, Taku
AU - Yamada, Noritaka
AU - Ogawa, Kenji
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/2
Y1 - 2016/2
N2 - [Background] Patients receiving surgical treatment for Mycobacterium avium complex (MAC), lung disease should be followed up with careful attention paid to relapse/ recurrence, but there is some debate regarding the findings based on which relapse/recurrence should be diagnosed. [Purpose and Methods] We hypothesized that we might be able to use anti-GPL core IgA antibodies (MAC antibodies), which have been attracting attention as a factor that may support diagnosis of MAC lung disease, to diagnose postoperative relapse/recurrence. Therefore, we compared the levels of these antibodies before and at the time of relapse/recurrence, and also compared antibody titers before and after surgery. [Result] MAC antibody titers were elevated by an average of about 50% at the time of relapse/recurrence compared to those before relapse/recurrence for 6 patients. In contrast, MAC antibody titers were about 30% lower after surgery compared to those before surgery for 37 patients. [Conclusion] It may be possible to use MAC antibodies as an indicator of postoperative relapse/recurrence for MAC lung disease.
AB - [Background] Patients receiving surgical treatment for Mycobacterium avium complex (MAC), lung disease should be followed up with careful attention paid to relapse/ recurrence, but there is some debate regarding the findings based on which relapse/recurrence should be diagnosed. [Purpose and Methods] We hypothesized that we might be able to use anti-GPL core IgA antibodies (MAC antibodies), which have been attracting attention as a factor that may support diagnosis of MAC lung disease, to diagnose postoperative relapse/recurrence. Therefore, we compared the levels of these antibodies before and at the time of relapse/recurrence, and also compared antibody titers before and after surgery. [Result] MAC antibody titers were elevated by an average of about 50% at the time of relapse/recurrence compared to those before relapse/recurrence for 6 patients. In contrast, MAC antibody titers were about 30% lower after surgery compared to those before surgery for 37 patients. [Conclusion] It may be possible to use MAC antibodies as an indicator of postoperative relapse/recurrence for MAC lung disease.
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M3 - Article
C2 - 27263223
AN - SCOPUS:84979097989
SN - 0022-9776
VL - 91
SP - 41
EP - 44
JO - Kekkaku
JF - Kekkaku
IS - 2
ER -