Changes in superoxide dismutase activities and concentrations and myeloperoxidase activities in leukocytes from patients with diabetes mellitus

Keiko Uchimura, Akio Nagasaka, Ritsuko Hayashi, Masaki Makino, Mutsuko Nagata, Hiroaki Kakizawa, Takako Kobayashi, Kentaro Fujiwara, Taiya Kato, Katsumi Iwase, Rikio Shinohara, Kanefusa Kato, Mitsuyasu Itoh

Research output: Contribution to journalArticlepeer-review

75 Citations (Scopus)

Abstract

To investigate whether the two free-radical scavengers, Cu, Zn- and Mn-superoxide dismutase (SOD), are changed in leukocytes of diabetic patients, and the alteration of these enzymes correlates with the diabetic state, we measured the activity and concentration of these enzymes in leukocytes from diabetic patients. Both Cu, Zn-SOD and Mn-SOD activities in neutrophils and lymphocytes were significantly lower in patients with non-insulin-dependent diabetes mellitus than in healthy controls. The concentrations of these enzymes in leukocytes from diabetic patients, however, did not differ from those in controls. Cu, Zn-SOD and Mn-SOD activities in neutrophils inversely correlated with HbA(1c) concentrations. Myeloperoxidase activity in leukocytes was significantly reduced in NIDDM patients. These findings suggest that changes in these enzymes may affect the susceptibility to infection and immunocompetence of patients with diabetes. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)264-270
Number of pages7
JournalJournal of Diabetes and its Complications
Volume13
Issue number5-6
DOIs
Publication statusPublished - 01-09-1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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