TY - JOUR
T1 - Changes in superoxide dismutase activities and concentrations and myeloperoxidase activities in leukocytes from patients with diabetes mellitus
AU - Uchimura, Keiko
AU - Nagasaka, Akio
AU - Hayashi, Ritsuko
AU - Makino, Masaki
AU - Nagata, Mutsuko
AU - Kakizawa, Hiroaki
AU - Kobayashi, Takako
AU - Fujiwara, Kentaro
AU - Kato, Taiya
AU - Iwase, Katsumi
AU - Shinohara, Rikio
AU - Kato, Kanefusa
AU - Itoh, Mitsuyasu
PY - 1999/9
Y1 - 1999/9
N2 - To investigate whether the two free-radical scavengers, Cu, Zn- and Mn-superoxide dismutase (SOD), are changed in leukocytes of diabetic patients, and the alteration of these enzymes correlates with the diabetic state, we measured the activity and concentration of these enzymes in leukocytes from diabetic patients. Both Cu, Zn-SOD and Mn-SOD activities in neutrophils and lymphocytes were significantly lower in patients with non-insulin-dependent diabetes mellitus than in healthy controls. The concentrations of these enzymes in leukocytes from diabetic patients, however, did not differ from those in controls. Cu, Zn-SOD and Mn-SOD activities in neutrophils inversely correlated with HbA(1c) concentrations. Myeloperoxidase activity in leukocytes was significantly reduced in NIDDM patients. These findings suggest that changes in these enzymes may affect the susceptibility to infection and immunocompetence of patients with diabetes. Copyright (C) 2000 Elsevier Science Inc.
AB - To investigate whether the two free-radical scavengers, Cu, Zn- and Mn-superoxide dismutase (SOD), are changed in leukocytes of diabetic patients, and the alteration of these enzymes correlates with the diabetic state, we measured the activity and concentration of these enzymes in leukocytes from diabetic patients. Both Cu, Zn-SOD and Mn-SOD activities in neutrophils and lymphocytes were significantly lower in patients with non-insulin-dependent diabetes mellitus than in healthy controls. The concentrations of these enzymes in leukocytes from diabetic patients, however, did not differ from those in controls. Cu, Zn-SOD and Mn-SOD activities in neutrophils inversely correlated with HbA(1c) concentrations. Myeloperoxidase activity in leukocytes was significantly reduced in NIDDM patients. These findings suggest that changes in these enzymes may affect the susceptibility to infection and immunocompetence of patients with diabetes. Copyright (C) 2000 Elsevier Science Inc.
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U2 - 10.1016/S1056-8727(99)00053-7
DO - 10.1016/S1056-8727(99)00053-7
M3 - Article
C2 - 10765000
AN - SCOPUS:0033549921
SN - 1056-8727
VL - 13
SP - 264
EP - 270
JO - Journal of Diabetes and its Complications
JF - Journal of Diabetes and its Complications
IS - 5-6
ER -