Changes in the numbers of patients with acute gastroenteritis after voluntary introduction of the rotavirus vaccine in a Japanese children's primary emergency medical center

Ichiro Morioka, Naohiro Kamiyoshi, Masahiro Nishiyama, Tomohiko Yamamura, Shogo Minamikawa, Sota Iwatani, Hiroaki Nagase, Kandai Nozu, Noriyuki Nishimura, Mariko Taniguchi-Ikeda, Kazuto Ishibashi, Akihito Ishida, Kazumoto Iijima

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Acute gastroenteritis (AGE) is a major reason for presentation to pediatric primary emergency medical centers. Because rotavirus vaccines were introduced in November 2011 for voluntary vaccination in Japan, we analyzed the changes in the numbers of AGE patients. Methods: The number and proportion of patients visiting Kobe children's primary emergency medical center from January 2011 to February 2015 due to AGE, out of all visiting children, were investigated retrospectively. The rotavirus and norovirus epidemic periods were defined as the periods from March to June and from November to February, respectively, based on their disease prevalence. Results: In patients ≤2 years of age, the numbers and proportions of patients with AGE were significantly decreased from 2464/14098 (17%) in 2011 to 1888/12321 (15%) in 2014 (p < 0.01). In patients ≤2 and 3-5 years of age, significant decreases in AGE patients between 2011 and 2014 were observed during the rotavirus season (from 20% [1090/5329] to 14% [642/4482] in patients aged ≤2 years and from 23% [704/3047] to 20% [572/2807] in patients aged 3-5 years, p < 0.01 and p < 0.05, respectively), but not during the norovirus season (from 19% [834/4436] to 19% [797/4160] in patients aged ≤2 years and from 20% [679/3334] to 25% [710/2852] in patients aged 3-5 years). Conclusions: The estimated rotavirus vaccine coverage in our area increased from 1% in 2011 to 49% in 2014; this coverage may have resulted in a reduction in AGE patients, both directly and indirectly, in our Japanese children's primary emergency medical center.

Original languageEnglish
JournalEnvironmental Health and Preventive Medicine
Volume22
Issue number1
DOIs
Publication statusPublished - 01-01-2017

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Rotavirus Vaccines
Gastroenteritis
Emergencies
Norovirus
Rotavirus
Japan
Vaccination

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

Morioka, Ichiro ; Kamiyoshi, Naohiro ; Nishiyama, Masahiro ; Yamamura, Tomohiko ; Minamikawa, Shogo ; Iwatani, Sota ; Nagase, Hiroaki ; Nozu, Kandai ; Nishimura, Noriyuki ; Taniguchi-Ikeda, Mariko ; Ishibashi, Kazuto ; Ishida, Akihito ; Iijima, Kazumoto. / Changes in the numbers of patients with acute gastroenteritis after voluntary introduction of the rotavirus vaccine in a Japanese children's primary emergency medical center. In: Environmental Health and Preventive Medicine. 2017 ; Vol. 22, No. 1.
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title = "Changes in the numbers of patients with acute gastroenteritis after voluntary introduction of the rotavirus vaccine in a Japanese children's primary emergency medical center",
abstract = "Background: Acute gastroenteritis (AGE) is a major reason for presentation to pediatric primary emergency medical centers. Because rotavirus vaccines were introduced in November 2011 for voluntary vaccination in Japan, we analyzed the changes in the numbers of AGE patients. Methods: The number and proportion of patients visiting Kobe children's primary emergency medical center from January 2011 to February 2015 due to AGE, out of all visiting children, were investigated retrospectively. The rotavirus and norovirus epidemic periods were defined as the periods from March to June and from November to February, respectively, based on their disease prevalence. Results: In patients ≤2 years of age, the numbers and proportions of patients with AGE were significantly decreased from 2464/14098 (17{\%}) in 2011 to 1888/12321 (15{\%}) in 2014 (p < 0.01). In patients ≤2 and 3-5 years of age, significant decreases in AGE patients between 2011 and 2014 were observed during the rotavirus season (from 20{\%} [1090/5329] to 14{\%} [642/4482] in patients aged ≤2 years and from 23{\%} [704/3047] to 20{\%} [572/2807] in patients aged 3-5 years, p < 0.01 and p < 0.05, respectively), but not during the norovirus season (from 19{\%} [834/4436] to 19{\%} [797/4160] in patients aged ≤2 years and from 20{\%} [679/3334] to 25{\%} [710/2852] in patients aged 3-5 years). Conclusions: The estimated rotavirus vaccine coverage in our area increased from 1{\%} in 2011 to 49{\%} in 2014; this coverage may have resulted in a reduction in AGE patients, both directly and indirectly, in our Japanese children's primary emergency medical center.",
author = "Ichiro Morioka and Naohiro Kamiyoshi and Masahiro Nishiyama and Tomohiko Yamamura and Shogo Minamikawa and Sota Iwatani and Hiroaki Nagase and Kandai Nozu and Noriyuki Nishimura and Mariko Taniguchi-Ikeda and Kazuto Ishibashi and Akihito Ishida and Kazumoto Iijima",
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Changes in the numbers of patients with acute gastroenteritis after voluntary introduction of the rotavirus vaccine in a Japanese children's primary emergency medical center. / Morioka, Ichiro; Kamiyoshi, Naohiro; Nishiyama, Masahiro; Yamamura, Tomohiko; Minamikawa, Shogo; Iwatani, Sota; Nagase, Hiroaki; Nozu, Kandai; Nishimura, Noriyuki; Taniguchi-Ikeda, Mariko; Ishibashi, Kazuto; Ishida, Akihito; Iijima, Kazumoto.

In: Environmental Health and Preventive Medicine, Vol. 22, No. 1, 01.01.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Changes in the numbers of patients with acute gastroenteritis after voluntary introduction of the rotavirus vaccine in a Japanese children's primary emergency medical center

AU - Morioka, Ichiro

AU - Kamiyoshi, Naohiro

AU - Nishiyama, Masahiro

AU - Yamamura, Tomohiko

AU - Minamikawa, Shogo

AU - Iwatani, Sota

AU - Nagase, Hiroaki

AU - Nozu, Kandai

AU - Nishimura, Noriyuki

AU - Taniguchi-Ikeda, Mariko

AU - Ishibashi, Kazuto

AU - Ishida, Akihito

AU - Iijima, Kazumoto

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background: Acute gastroenteritis (AGE) is a major reason for presentation to pediatric primary emergency medical centers. Because rotavirus vaccines were introduced in November 2011 for voluntary vaccination in Japan, we analyzed the changes in the numbers of AGE patients. Methods: The number and proportion of patients visiting Kobe children's primary emergency medical center from January 2011 to February 2015 due to AGE, out of all visiting children, were investigated retrospectively. The rotavirus and norovirus epidemic periods were defined as the periods from March to June and from November to February, respectively, based on their disease prevalence. Results: In patients ≤2 years of age, the numbers and proportions of patients with AGE were significantly decreased from 2464/14098 (17%) in 2011 to 1888/12321 (15%) in 2014 (p < 0.01). In patients ≤2 and 3-5 years of age, significant decreases in AGE patients between 2011 and 2014 were observed during the rotavirus season (from 20% [1090/5329] to 14% [642/4482] in patients aged ≤2 years and from 23% [704/3047] to 20% [572/2807] in patients aged 3-5 years, p < 0.01 and p < 0.05, respectively), but not during the norovirus season (from 19% [834/4436] to 19% [797/4160] in patients aged ≤2 years and from 20% [679/3334] to 25% [710/2852] in patients aged 3-5 years). Conclusions: The estimated rotavirus vaccine coverage in our area increased from 1% in 2011 to 49% in 2014; this coverage may have resulted in a reduction in AGE patients, both directly and indirectly, in our Japanese children's primary emergency medical center.

AB - Background: Acute gastroenteritis (AGE) is a major reason for presentation to pediatric primary emergency medical centers. Because rotavirus vaccines were introduced in November 2011 for voluntary vaccination in Japan, we analyzed the changes in the numbers of AGE patients. Methods: The number and proportion of patients visiting Kobe children's primary emergency medical center from January 2011 to February 2015 due to AGE, out of all visiting children, were investigated retrospectively. The rotavirus and norovirus epidemic periods were defined as the periods from March to June and from November to February, respectively, based on their disease prevalence. Results: In patients ≤2 years of age, the numbers and proportions of patients with AGE were significantly decreased from 2464/14098 (17%) in 2011 to 1888/12321 (15%) in 2014 (p < 0.01). In patients ≤2 and 3-5 years of age, significant decreases in AGE patients between 2011 and 2014 were observed during the rotavirus season (from 20% [1090/5329] to 14% [642/4482] in patients aged ≤2 years and from 23% [704/3047] to 20% [572/2807] in patients aged 3-5 years, p < 0.01 and p < 0.05, respectively), but not during the norovirus season (from 19% [834/4436] to 19% [797/4160] in patients aged ≤2 years and from 20% [679/3334] to 25% [710/2852] in patients aged 3-5 years). Conclusions: The estimated rotavirus vaccine coverage in our area increased from 1% in 2011 to 49% in 2014; this coverage may have resulted in a reduction in AGE patients, both directly and indirectly, in our Japanese children's primary emergency medical center.

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U2 - 10.1186/s12199-017-0638-3

DO - 10.1186/s12199-017-0638-3

M3 - Article

AN - SCOPUS:85031744756

VL - 22

JO - Environmental Health and Preventive Medicine

JF - Environmental Health and Preventive Medicine

SN - 1342-078X

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