Changes in the peripheral eosinophil count in patients with acute eosinophilic myocarditis

Shin Ichiro Morimoto, Natsuko Kubo, Shinya Hiramitsu, Akihisa Uemura, Masatsugu Ohtsuki, Shigeru Kato, Yasuchika Kato, Atsushi Sugiura, Kenji Miyagishima, Nami Mori, Yukihiko Yoshida, Hitoshi Hishida

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)


In many cases, the diagnosis of eosinophilic myocarditis is suggested by an elevated peripheral blood eosinophil count. However, no detailed studies have been performed on the sequential changes in the initial peripheral blood eosinophil count over the course of the disease. We measured the peripheral blood eosinophil count at the time of presentation in eight patients with eosinophilic myocarditis proven by endomyocardial biopsy and intermittently thereafter. The eosinophil count at the time of onset was <500/mm3 in four patients, >500/mm3 but <1000/mm3 in three patients, and ≧1000/mm3 in one patient. In three of the four patients with an initial eosinophil count of <500/mm3, an increase to ≧500/mm3 occurred 7-12 days after the onset. The remaining patient did not develop peripheral eosinophilia. In conclusion, in the early stage of eosinophilic myocarditis, peripheral hypereosinophilia is not present initially in some patients, and may not develop during the course of the illness in a subset of these patients.

Original languageEnglish
Pages (from-to)193-196
Number of pages4
JournalHeart and Vessels
Issue number4
Publication statusPublished - 09-2003

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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