Changes in tryptophan metabolism during pregnancy and postpartum periods

Potential involvement in postpartum depressive symptoms

Tomoaki Teshigawara, Akihiro Mouri, Hisako Kubo, Yukako Nakamura, Tomoko Shiino, Takashi Okada, Mako Morikawa, Toshitaka Nabeshima, Norio Ozaki, Yasuko Yamamoto, Kuniaki Saito

Research output: Contribution to journalArticle

Abstract

Background: Many women experience depressive symptoms during pregnancy and postpartum periods. These depressive symptoms are often accompanied by other inflammatory morbidities present during pregnancy. Tryptophan (TRP) metabolism has attracted considerable attention due to its influence on the onset of depression via induction of inflammation. We examined the changes in plasma levels of TRP metabolites in pregnant women with depressive symptoms during pregnancy and/or the postpartum period. Methods: In line with a previous analysis using the Edinburgh Postnatal Depression Scale (EPDS), participants were divided into a non-depressive (ND) group, a postpartum depressive (PD) group, a temporary gestational depressive (TG) group, and a continuous depressive (CD) group. Blood samples were collected before and 1 month after delivery. The concentrations of plasma TRP metabolites were measured using high-performance liquid chromatography (HPLC). Results: There are differences in plasma levels of TRP metabolites during pregnancy and postpartum periods between the ND group and the PD group, but not the TG or CD group. In the PD group, plasma levels of kynurenine (KYN) and kynurenic acid (KA), and KYN/TRP and KA/KYN ratio during the pregnancy period were higher and 3-hydroxyanthranilic acid (3HAA) during the postpartum period was lower than those in the ND group. Limitations: Histories regarding mood disorders before pregnancy were not assessed. Conclusions: The higher plasma levels of KYN and KA, and KYN/TRP and KA/KYN ratio during pregnancy period and lower plasma level of 3HAA during the postpartum period could be useful predictive and diagnostic markers of postpartum depressive symptoms.

Original languageEnglish
Pages (from-to)168-176
Number of pages9
JournalJournal of Affective Disorders
Volume255
DOIs
Publication statusPublished - 01-08-2019

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Tryptophan
Postpartum Period
Kynurenine
Depression
Pregnancy
Kynurenic Acid
3-Hydroxyanthranilic Acid
Postpartum Depression
Mood Disorders
Pregnant Women
High Pressure Liquid Chromatography
Inflammation
Morbidity

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Teshigawara, Tomoaki ; Mouri, Akihiro ; Kubo, Hisako ; Nakamura, Yukako ; Shiino, Tomoko ; Okada, Takashi ; Morikawa, Mako ; Nabeshima, Toshitaka ; Ozaki, Norio ; Yamamoto, Yasuko ; Saito, Kuniaki. / Changes in tryptophan metabolism during pregnancy and postpartum periods : Potential involvement in postpartum depressive symptoms. In: Journal of Affective Disorders. 2019 ; Vol. 255. pp. 168-176.
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abstract = "Background: Many women experience depressive symptoms during pregnancy and postpartum periods. These depressive symptoms are often accompanied by other inflammatory morbidities present during pregnancy. Tryptophan (TRP) metabolism has attracted considerable attention due to its influence on the onset of depression via induction of inflammation. We examined the changes in plasma levels of TRP metabolites in pregnant women with depressive symptoms during pregnancy and/or the postpartum period. Methods: In line with a previous analysis using the Edinburgh Postnatal Depression Scale (EPDS), participants were divided into a non-depressive (ND) group, a postpartum depressive (PD) group, a temporary gestational depressive (TG) group, and a continuous depressive (CD) group. Blood samples were collected before and 1 month after delivery. The concentrations of plasma TRP metabolites were measured using high-performance liquid chromatography (HPLC). Results: There are differences in plasma levels of TRP metabolites during pregnancy and postpartum periods between the ND group and the PD group, but not the TG or CD group. In the PD group, plasma levels of kynurenine (KYN) and kynurenic acid (KA), and KYN/TRP and KA/KYN ratio during the pregnancy period were higher and 3-hydroxyanthranilic acid (3HAA) during the postpartum period was lower than those in the ND group. Limitations: Histories regarding mood disorders before pregnancy were not assessed. Conclusions: The higher plasma levels of KYN and KA, and KYN/TRP and KA/KYN ratio during pregnancy period and lower plasma level of 3HAA during the postpartum period could be useful predictive and diagnostic markers of postpartum depressive symptoms.",
author = "Tomoaki Teshigawara and Akihiro Mouri and Hisako Kubo and Yukako Nakamura and Tomoko Shiino and Takashi Okada and Mako Morikawa and Toshitaka Nabeshima and Norio Ozaki and Yasuko Yamamoto and Kuniaki Saito",
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Changes in tryptophan metabolism during pregnancy and postpartum periods : Potential involvement in postpartum depressive symptoms. / Teshigawara, Tomoaki; Mouri, Akihiro; Kubo, Hisako; Nakamura, Yukako; Shiino, Tomoko; Okada, Takashi; Morikawa, Mako; Nabeshima, Toshitaka; Ozaki, Norio; Yamamoto, Yasuko; Saito, Kuniaki.

In: Journal of Affective Disorders, Vol. 255, 01.08.2019, p. 168-176.

Research output: Contribution to journalArticle

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T1 - Changes in tryptophan metabolism during pregnancy and postpartum periods

T2 - Potential involvement in postpartum depressive symptoms

AU - Teshigawara, Tomoaki

AU - Mouri, Akihiro

AU - Kubo, Hisako

AU - Nakamura, Yukako

AU - Shiino, Tomoko

AU - Okada, Takashi

AU - Morikawa, Mako

AU - Nabeshima, Toshitaka

AU - Ozaki, Norio

AU - Yamamoto, Yasuko

AU - Saito, Kuniaki

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Background: Many women experience depressive symptoms during pregnancy and postpartum periods. These depressive symptoms are often accompanied by other inflammatory morbidities present during pregnancy. Tryptophan (TRP) metabolism has attracted considerable attention due to its influence on the onset of depression via induction of inflammation. We examined the changes in plasma levels of TRP metabolites in pregnant women with depressive symptoms during pregnancy and/or the postpartum period. Methods: In line with a previous analysis using the Edinburgh Postnatal Depression Scale (EPDS), participants were divided into a non-depressive (ND) group, a postpartum depressive (PD) group, a temporary gestational depressive (TG) group, and a continuous depressive (CD) group. Blood samples were collected before and 1 month after delivery. The concentrations of plasma TRP metabolites were measured using high-performance liquid chromatography (HPLC). Results: There are differences in plasma levels of TRP metabolites during pregnancy and postpartum periods between the ND group and the PD group, but not the TG or CD group. In the PD group, plasma levels of kynurenine (KYN) and kynurenic acid (KA), and KYN/TRP and KA/KYN ratio during the pregnancy period were higher and 3-hydroxyanthranilic acid (3HAA) during the postpartum period was lower than those in the ND group. Limitations: Histories regarding mood disorders before pregnancy were not assessed. Conclusions: The higher plasma levels of KYN and KA, and KYN/TRP and KA/KYN ratio during pregnancy period and lower plasma level of 3HAA during the postpartum period could be useful predictive and diagnostic markers of postpartum depressive symptoms.

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