Changes of an androgen-dependent nuclear protein during functional differentiation and by dedifferentiation of the dorsolateral prostate of rats

Yuhsi Matuo; Nozomu Nishi; Yukio Tanaka; Yasuyoshi Muguruma; Koichiro Tanaka; Yoshiki Akatsuka; Sei Ichi Matsui; Avery A. Sandberg; Fumio Wada

doi:10.1016/0006-291X(84)91326-3

Changes of an androgen-dependent nuclear protein during functional differentiation and by dedifferentiation of the dorsolateral prostate of rats

Yuhsi Matuo, Nozomu Nishi, Yukio Tanaka, Yasuyoshi Muguruma, Koichiro Tanaka, Yoshiki Akatsuka, Sei Ichi Matsui, Avery A. Sandberg, Fumio Wada

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Abstract

Nuclei of the dorsolateral prostate of rats contain a large amount of androgen-dependent non-histone protein (20K-NHP) (mol. wt. ≒ 20,000; pI ≒ 11.5) (Matuo et al. (1)). Its content in the nuclei increased most markedly during 4-8 weeks of age, when functional differentiation of the prostate was most active on the basis of the changes of major cytosol proteins and zinc. Nuclei of the Dunning tumors originating in the dorsolateral prostate were found to lack 20K-NHP regardless of androgen dependency, indicating the disappearance of the 20K-NHP from the nuclei by defifferentiation. These suggest that the 20K-NHP is an important nuclear protein for differentiation of the dorsolateral prostate cells.

Original language	English
Pages (from-to)	467-473
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	118
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(84)91326-3
Publication status	Published - 30-01-1984
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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Matuo, Y., Nishi, N., Tanaka, Y., Muguruma, Y., Tanaka, K., Akatsuka, Y., Matsui, S. I., Sandberg, A. A., & Wada, F. (1984). Changes of an androgen-dependent nuclear protein during functional differentiation and by dedifferentiation of the dorsolateral prostate of rats. Biochemical and Biophysical Research Communications, 118(2), 467-473. https://doi.org/10.1016/0006-291X(84)91326-3

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title = "Changes of an androgen-dependent nuclear protein during functional differentiation and by dedifferentiation of the dorsolateral prostate of rats",

abstract = "Nuclei of the dorsolateral prostate of rats contain a large amount of androgen-dependent non-histone protein (20K-NHP) (mol. wt. ≒ 20,000; pI ≒ 11.5) (Matuo et al. (1)). Its content in the nuclei increased most markedly during 4-8 weeks of age, when functional differentiation of the prostate was most active on the basis of the changes of major cytosol proteins and zinc. Nuclei of the Dunning tumors originating in the dorsolateral prostate were found to lack 20K-NHP regardless of androgen dependency, indicating the disappearance of the 20K-NHP from the nuclei by defifferentiation. These suggest that the 20K-NHP is an important nuclear protein for differentiation of the dorsolateral prostate cells.",

author = "Yuhsi Matuo and Nozomu Nishi and Yukio Tanaka and Yasuyoshi Muguruma and Koichiro Tanaka and Yoshiki Akatsuka and Matsui, {Sei Ichi} and Sandberg, {Avery A.} and Fumio Wada",

year = "1984",

month = jan,

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doi = "10.1016/0006-291X(84)91326-3",

language = "English",

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journal = "Biochemical and Biophysical Research Communications",

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Matuo, Y, Nishi, N, Tanaka, Y, Muguruma, Y, Tanaka, K, Akatsuka, Y, Matsui, SI, Sandberg, AA & Wada, F 1984, 'Changes of an androgen-dependent nuclear protein during functional differentiation and by dedifferentiation of the dorsolateral prostate of rats', Biochemical and Biophysical Research Communications, vol. 118, no. 2, pp. 467-473. https://doi.org/10.1016/0006-291X(84)91326-3

TY - JOUR

T1 - Changes of an androgen-dependent nuclear protein during functional differentiation and by dedifferentiation of the dorsolateral prostate of rats

AU - Matuo, Yuhsi

AU - Nishi, Nozomu

AU - Tanaka, Yukio

AU - Muguruma, Yasuyoshi

AU - Tanaka, Koichiro

AU - Akatsuka, Yoshiki

AU - Matsui, Sei Ichi

AU - Sandberg, Avery A.

AU - Wada, Fumio

PY - 1984/1/30

Y1 - 1984/1/30

N2 - Nuclei of the dorsolateral prostate of rats contain a large amount of androgen-dependent non-histone protein (20K-NHP) (mol. wt. ≒ 20,000; pI ≒ 11.5) (Matuo et al. (1)). Its content in the nuclei increased most markedly during 4-8 weeks of age, when functional differentiation of the prostate was most active on the basis of the changes of major cytosol proteins and zinc. Nuclei of the Dunning tumors originating in the dorsolateral prostate were found to lack 20K-NHP regardless of androgen dependency, indicating the disappearance of the 20K-NHP from the nuclei by defifferentiation. These suggest that the 20K-NHP is an important nuclear protein for differentiation of the dorsolateral prostate cells.

AB - Nuclei of the dorsolateral prostate of rats contain a large amount of androgen-dependent non-histone protein (20K-NHP) (mol. wt. ≒ 20,000; pI ≒ 11.5) (Matuo et al. (1)). Its content in the nuclei increased most markedly during 4-8 weeks of age, when functional differentiation of the prostate was most active on the basis of the changes of major cytosol proteins and zinc. Nuclei of the Dunning tumors originating in the dorsolateral prostate were found to lack 20K-NHP regardless of androgen dependency, indicating the disappearance of the 20K-NHP from the nuclei by defifferentiation. These suggest that the 20K-NHP is an important nuclear protein for differentiation of the dorsolateral prostate cells.

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SN - 0006-291X

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JO - Biochemical and Biophysical Research Communications

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Changes of an androgen-dependent nuclear protein during functional differentiation and by dedifferentiation of the dorsolateral prostate of rats

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