TY - JOUR
T1 - Changes of Contractile Properties of Extensor Digitorum Longus in Response to Creatine-Analogue Administration and/or Hindlimb Suspension in Rats
AU - Wakatsuki, T.
AU - Ohira, Y.
AU - Nakamura, K.
AU - Asakura, T.
AU - Ohno, H.
AU - Yamamoto, M.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1995
Y1 - 1995
N2 - Changes of contractile properties of extensor digitorum longus in response to hindlimb suspension and/or altered high-energy phosphate contents were studied in rats. A reduction of high-energy phosphates, especially phosphocreatine, was seen in rats fed creatine analogue β-guanidinopropionic acid (β-GPA), but they were elevated after 10-d supplementation of creatine. The one-half relaxation time was increased by feeding β-GPA, but was normalized by creatine supply. The fatigue resistance of creatine-depleted muscle was significantly improved, but tended to decrease by suspension and creatine supply, although it was still better than that in the control diet group. It is indicated that the contractile properties of muscle are influenced by the high-energy phosphate content. It is also suggested that the endurance capacity may be influenced by the mitochondrial respiratory capacity, but not necessarily by the levels of high-energy phosphates.
AB - Changes of contractile properties of extensor digitorum longus in response to hindlimb suspension and/or altered high-energy phosphate contents were studied in rats. A reduction of high-energy phosphates, especially phosphocreatine, was seen in rats fed creatine analogue β-guanidinopropionic acid (β-GPA), but they were elevated after 10-d supplementation of creatine. The one-half relaxation time was increased by feeding β-GPA, but was normalized by creatine supply. The fatigue resistance of creatine-depleted muscle was significantly improved, but tended to decrease by suspension and creatine supply, although it was still better than that in the control diet group. It is indicated that the contractile properties of muscle are influenced by the high-energy phosphate content. It is also suggested that the endurance capacity may be influenced by the mitochondrial respiratory capacity, but not necessarily by the levels of high-energy phosphates.
UR - http://www.scopus.com/inward/record.url?scp=0029556224&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029556224&partnerID=8YFLogxK
U2 - 10.2170/jjphysiol.45.979
DO - 10.2170/jjphysiol.45.979
M3 - Article
C2 - 8676581
AN - SCOPUS:0029556224
SN - 0021-521X
VL - 45
SP - 979
EP - 989
JO - Japanese Journal of Physiology
JF - Japanese Journal of Physiology
IS - 6
ER -