Changes of shear-wave velocity by interferon-based therapy in chronic hepatitis C

Keisuke Osakabe, Naohiro Ichino, Toru Nishikawa, Hiroko Sugiyama, Miho Kato, Ai Shibata, Wakana Asada, Naoto Kawabe, Senju Hashimoto, Michihito Murao, Takuji Nakano, Hiroaki Shimazaki, Toshiki Kan, Kazunori Nakaoka, Yuka Takagawa, Masashi Ohki, Takamitsu Kurashita, Tomoki Takamura, Kentaro Yoshioka

Research output: Contribution to journalArticle

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Abstract

AIM: To evaluate the changes of shear-wave velocity (Vs) by acoustic radiation force impulse after treatment in chronic hepatitis C. METHODS: Eighty-seven patients with chronic hepatitis C were consecutively treated with combinations of interferon (IFN) plus ribavirin (RBV). Vs value (m/s) was measured with acoustic radiation force impulse before treatment, at end of treatment (EOT), 1 year after EOT, and 2 years after EOT. RESULTS: In patients with a sustained virological response (SVR) (n = 41), Vs significantly decreased at EOT [1.19 (1.07-1.37), P = 0.0004], 1 year after EOT [1.10 (1.00-1.22), P = 0.0001], and 2 years after EOT [1.05 (0.95-1.16), P < 0.0001] compared with baseline [1.27 (1.11-1.49)]. In patients with a relapse (n = 26), Vs did not significantly decrease at EOT [1.23 (1.12-1.55)], 1 year after EOT [1.20 (1.12-1.80)], and 2 years after EOT [1.41 (1.08-2.01)] compared with baseline [1.39 (1.15-1.57)]. In patients with a nonvirological response (n = 20), Vs did not significantly decrease at EOT [1.64 (1.43-2.06)], 1 year after EOT [1.66 (1.30-1.95)], and 2 years after EOT [1.61 (1.36-2.37)] compared with baseline [1.80 (1.54-2.01)]. Among genotype 1 patients, baseline Vs was significantly lower in SVR patients [1.28 (1.04-1.40)] than in non-SVR patients [1.56 (1.20-1.83)] (P = 0.0142). CONCLUSION: Reduction of Vs values was shown in SVR patients after IFN-plus-RBV therapy by acoustic radiation force impulse.

Original languageEnglish
Pages (from-to)10215-10223
Number of pages9
JournalWorld Journal of Gastroenterology
Volume21
Issue number35
DOIs
Publication statusPublished - 21-09-2015

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Chronic Hepatitis C
Interferons
Therapeutics
Acoustics
Ribavirin
Radiation
Radiotherapy

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Osakabe, Keisuke ; Ichino, Naohiro ; Nishikawa, Toru ; Sugiyama, Hiroko ; Kato, Miho ; Shibata, Ai ; Asada, Wakana ; Kawabe, Naoto ; Hashimoto, Senju ; Murao, Michihito ; Nakano, Takuji ; Shimazaki, Hiroaki ; Kan, Toshiki ; Nakaoka, Kazunori ; Takagawa, Yuka ; Ohki, Masashi ; Kurashita, Takamitsu ; Takamura, Tomoki ; Yoshioka, Kentaro. / Changes of shear-wave velocity by interferon-based therapy in chronic hepatitis C. In: World Journal of Gastroenterology. 2015 ; Vol. 21, No. 35. pp. 10215-10223.
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title = "Changes of shear-wave velocity by interferon-based therapy in chronic hepatitis C",
abstract = "AIM: To evaluate the changes of shear-wave velocity (Vs) by acoustic radiation force impulse after treatment in chronic hepatitis C. METHODS: Eighty-seven patients with chronic hepatitis C were consecutively treated with combinations of interferon (IFN) plus ribavirin (RBV). Vs value (m/s) was measured with acoustic radiation force impulse before treatment, at end of treatment (EOT), 1 year after EOT, and 2 years after EOT. RESULTS: In patients with a sustained virological response (SVR) (n = 41), Vs significantly decreased at EOT [1.19 (1.07-1.37), P = 0.0004], 1 year after EOT [1.10 (1.00-1.22), P = 0.0001], and 2 years after EOT [1.05 (0.95-1.16), P < 0.0001] compared with baseline [1.27 (1.11-1.49)]. In patients with a relapse (n = 26), Vs did not significantly decrease at EOT [1.23 (1.12-1.55)], 1 year after EOT [1.20 (1.12-1.80)], and 2 years after EOT [1.41 (1.08-2.01)] compared with baseline [1.39 (1.15-1.57)]. In patients with a nonvirological response (n = 20), Vs did not significantly decrease at EOT [1.64 (1.43-2.06)], 1 year after EOT [1.66 (1.30-1.95)], and 2 years after EOT [1.61 (1.36-2.37)] compared with baseline [1.80 (1.54-2.01)]. Among genotype 1 patients, baseline Vs was significantly lower in SVR patients [1.28 (1.04-1.40)] than in non-SVR patients [1.56 (1.20-1.83)] (P = 0.0142). CONCLUSION: Reduction of Vs values was shown in SVR patients after IFN-plus-RBV therapy by acoustic radiation force impulse.",
author = "Keisuke Osakabe and Naohiro Ichino and Toru Nishikawa and Hiroko Sugiyama and Miho Kato and Ai Shibata and Wakana Asada and Naoto Kawabe and Senju Hashimoto and Michihito Murao and Takuji Nakano and Hiroaki Shimazaki and Toshiki Kan and Kazunori Nakaoka and Yuka Takagawa and Masashi Ohki and Takamitsu Kurashita and Tomoki Takamura and Kentaro Yoshioka",
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Osakabe, K, Ichino, N, Nishikawa, T, Sugiyama, H, Kato, M, Shibata, A, Asada, W, Kawabe, N, Hashimoto, S, Murao, M, Nakano, T, Shimazaki, H, Kan, T, Nakaoka, K, Takagawa, Y, Ohki, M, Kurashita, T, Takamura, T & Yoshioka, K 2015, 'Changes of shear-wave velocity by interferon-based therapy in chronic hepatitis C', World Journal of Gastroenterology, vol. 21, no. 35, pp. 10215-10223. https://doi.org/10.3748/wjg.v21.i35.10215

Changes of shear-wave velocity by interferon-based therapy in chronic hepatitis C. / Osakabe, Keisuke; Ichino, Naohiro; Nishikawa, Toru; Sugiyama, Hiroko; Kato, Miho; Shibata, Ai; Asada, Wakana; Kawabe, Naoto; Hashimoto, Senju; Murao, Michihito; Nakano, Takuji; Shimazaki, Hiroaki; Kan, Toshiki; Nakaoka, Kazunori; Takagawa, Yuka; Ohki, Masashi; Kurashita, Takamitsu; Takamura, Tomoki; Yoshioka, Kentaro.

In: World Journal of Gastroenterology, Vol. 21, No. 35, 21.09.2015, p. 10215-10223.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Changes of shear-wave velocity by interferon-based therapy in chronic hepatitis C

AU - Osakabe, Keisuke

AU - Ichino, Naohiro

AU - Nishikawa, Toru

AU - Sugiyama, Hiroko

AU - Kato, Miho

AU - Shibata, Ai

AU - Asada, Wakana

AU - Kawabe, Naoto

AU - Hashimoto, Senju

AU - Murao, Michihito

AU - Nakano, Takuji

AU - Shimazaki, Hiroaki

AU - Kan, Toshiki

AU - Nakaoka, Kazunori

AU - Takagawa, Yuka

AU - Ohki, Masashi

AU - Kurashita, Takamitsu

AU - Takamura, Tomoki

AU - Yoshioka, Kentaro

PY - 2015/9/21

Y1 - 2015/9/21

N2 - AIM: To evaluate the changes of shear-wave velocity (Vs) by acoustic radiation force impulse after treatment in chronic hepatitis C. METHODS: Eighty-seven patients with chronic hepatitis C were consecutively treated with combinations of interferon (IFN) plus ribavirin (RBV). Vs value (m/s) was measured with acoustic radiation force impulse before treatment, at end of treatment (EOT), 1 year after EOT, and 2 years after EOT. RESULTS: In patients with a sustained virological response (SVR) (n = 41), Vs significantly decreased at EOT [1.19 (1.07-1.37), P = 0.0004], 1 year after EOT [1.10 (1.00-1.22), P = 0.0001], and 2 years after EOT [1.05 (0.95-1.16), P < 0.0001] compared with baseline [1.27 (1.11-1.49)]. In patients with a relapse (n = 26), Vs did not significantly decrease at EOT [1.23 (1.12-1.55)], 1 year after EOT [1.20 (1.12-1.80)], and 2 years after EOT [1.41 (1.08-2.01)] compared with baseline [1.39 (1.15-1.57)]. In patients with a nonvirological response (n = 20), Vs did not significantly decrease at EOT [1.64 (1.43-2.06)], 1 year after EOT [1.66 (1.30-1.95)], and 2 years after EOT [1.61 (1.36-2.37)] compared with baseline [1.80 (1.54-2.01)]. Among genotype 1 patients, baseline Vs was significantly lower in SVR patients [1.28 (1.04-1.40)] than in non-SVR patients [1.56 (1.20-1.83)] (P = 0.0142). CONCLUSION: Reduction of Vs values was shown in SVR patients after IFN-plus-RBV therapy by acoustic radiation force impulse.

AB - AIM: To evaluate the changes of shear-wave velocity (Vs) by acoustic radiation force impulse after treatment in chronic hepatitis C. METHODS: Eighty-seven patients with chronic hepatitis C were consecutively treated with combinations of interferon (IFN) plus ribavirin (RBV). Vs value (m/s) was measured with acoustic radiation force impulse before treatment, at end of treatment (EOT), 1 year after EOT, and 2 years after EOT. RESULTS: In patients with a sustained virological response (SVR) (n = 41), Vs significantly decreased at EOT [1.19 (1.07-1.37), P = 0.0004], 1 year after EOT [1.10 (1.00-1.22), P = 0.0001], and 2 years after EOT [1.05 (0.95-1.16), P < 0.0001] compared with baseline [1.27 (1.11-1.49)]. In patients with a relapse (n = 26), Vs did not significantly decrease at EOT [1.23 (1.12-1.55)], 1 year after EOT [1.20 (1.12-1.80)], and 2 years after EOT [1.41 (1.08-2.01)] compared with baseline [1.39 (1.15-1.57)]. In patients with a nonvirological response (n = 20), Vs did not significantly decrease at EOT [1.64 (1.43-2.06)], 1 year after EOT [1.66 (1.30-1.95)], and 2 years after EOT [1.61 (1.36-2.37)] compared with baseline [1.80 (1.54-2.01)]. Among genotype 1 patients, baseline Vs was significantly lower in SVR patients [1.28 (1.04-1.40)] than in non-SVR patients [1.56 (1.20-1.83)] (P = 0.0142). CONCLUSION: Reduction of Vs values was shown in SVR patients after IFN-plus-RBV therapy by acoustic radiation force impulse.

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