Changes of shear-wave velocity by interferon-based therapy in chronic hepatitis C

Keisuke Osakabe, Naohiro Ichino, Toru Nishikawa, Hiroko Sugiyama, Miho Kato, Ai Shibata, Wakana Asada, Naoto Kawabe, Senju Hashimoto, Michihito Murao, Takuji Nakano, Hiroaki Shimazaki, Toshiki Kan, Kazunori Nakaoka, Yuka Takagawa, Masashi Ohki, Takamitsu Kurashita, Tomoki Takamura, Kentaro Yoshioka

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Abstract

AIM: To evaluate the changes of shear-wave velocity (Vs) by acoustic radiation force impulse after treatment in chronic hepatitis C. METHODS: Eighty-seven patients with chronic hepatitis C were consecutively treated with combinations of interferon (IFN) plus ribavirin (RBV). Vs value (m/s) was measured with acoustic radiation force impulse before treatment, at end of treatment (EOT), 1 year after EOT, and 2 years after EOT. RESULTS: In patients with a sustained virological response (SVR) (n = 41), Vs significantly decreased at EOT [1.19 (1.07-1.37), P = 0.0004], 1 year after EOT [1.10 (1.00-1.22), P = 0.0001], and 2 years after EOT [1.05 (0.95-1.16), P < 0.0001] compared with baseline [1.27 (1.11-1.49)]. In patients with a relapse (n = 26), Vs did not significantly decrease at EOT [1.23 (1.12-1.55)], 1 year after EOT [1.20 (1.12-1.80)], and 2 years after EOT [1.41 (1.08-2.01)] compared with baseline [1.39 (1.15-1.57)]. In patients with a nonvirological response (n = 20), Vs did not significantly decrease at EOT [1.64 (1.43-2.06)], 1 year after EOT [1.66 (1.30-1.95)], and 2 years after EOT [1.61 (1.36-2.37)] compared with baseline [1.80 (1.54-2.01)]. Among genotype 1 patients, baseline Vs was significantly lower in SVR patients [1.28 (1.04-1.40)] than in non-SVR patients [1.56 (1.20-1.83)] (P = 0.0142). CONCLUSION: Reduction of Vs values was shown in SVR patients after IFN-plus-RBV therapy by acoustic radiation force impulse.

Original languageEnglish
Pages (from-to)10215-10223
Number of pages9
JournalWorld Journal of Gastroenterology
Volume21
Issue number35
DOIs
Publication statusPublished - 21-09-2015

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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    Osakabe, K., Ichino, N., Nishikawa, T., Sugiyama, H., Kato, M., Shibata, A., Asada, W., Kawabe, N., Hashimoto, S., Murao, M., Nakano, T., Shimazaki, H., Kan, T., Nakaoka, K., Takagawa, Y., Ohki, M., Kurashita, T., Takamura, T., & Yoshioka, K. (2015). Changes of shear-wave velocity by interferon-based therapy in chronic hepatitis C. World Journal of Gastroenterology, 21(35), 10215-10223. https://doi.org/10.3748/wjg.v21.i35.10215